Standard Name	BRE5
Systematic Name	YNR051C
Feature Type	ORF, Verified
Description	Ubiquitin protease cofactor, forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the endoplasmic reticulum and Golgi compartments; null is sensitive to brefeldin A (1, 2)
Name Description	BREfeldin A sensitivity 1

Chromosomal Location	ChrXIV:718327 to 716780 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for BRE5
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	protein deubiquitination (IMP) regulation of ER to Golgi vesicle-mediated transport (IMP) regulation of retrograde vesicle-mediated transport, Golgi to ER (IMP) ribophagy (IMP)
Cellular Component
High-throughput	cytoplasm (IDA)

Classical genetics
null	heat sensitivity: increased meiosis: abnormal metal resistance: decreased protein transport: abnormal replicative lifespan: increased resistance to brefeldin A: decreased resistance to hydroxyurea: decreased
Large-scale survey
null	acid pH resistance: decreased glutathione excretion: increased chitin deposition: increased competitive fitness: decreased filamentous growth: decreased invasive growth: absent replicative lifespan: increased resistance to ethanol: decreased resistance to PM02734: decreased resistance to monensin: decreased resistance to Calcofluor White: decreased resistance to methyl methanesulfonate: increased resistance to fenpropimorph: increased resistance to cycloheximide: decreased resistance to neomycin: decreased resistance to arsenite(3-): decreased resistance to caffeine: decreased resistance to quinine: decreased resistance to fluconazole: decreased resistance to hydroxyurea: decreased resistance to tunicamycin: decreased resistance to boric acid: decreased resistance to sodium selenide: decreased resistance to clioquinol: decreased resistance to BPS: decreased resistance to bleomycin: decreased sporulation: abnormal stress resistance: decreased viable
overexpression	resistance to sirolimus: increased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	1413 total interaction(s) for 899 unique genes/features.
Physical Interactions	Affinity Capture-MS: 398 Affinity Capture-RNA: 2 Affinity Capture-Western: 7 Co-crystal Structure: 2 Co-purification: 1 PCA: 5 Reconstituted Complex: 3 Two-hybrid: 3
Genetic Interactions	Negative Genetic: 689 Phenotypic Enhancement: 27 Phenotypic Suppression: 38 Positive Genetic: 157 Synthetic Growth Defect: 51 Synthetic Lethality: 25 Synthetic Rescue: 5
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIV:718327 to 716780 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1548 718327..716780 2011-02-03 1997-01-28
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005334