BPL1/YDL141W Summary Help

Standard Name BPL1 1
Systematic Name YDL141W
Alias ACC2 2
Feature Type ORF, Verified
Description Biotin:apoprotein ligase; covalently modifies proteins with the addition of biotin, required for acetyl-CoA carboxylase (Acc1p) holoenzyme formation (1, 3 and see Summary Paragraph)
Name Description Biotin:apoProtein Ligase 1
Chromosomal Location
ChrIV:203039 to 205111 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All BPL1 GO evidence and references
  View Computational GO annotations for BPL1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 2 genes
Resources
Classical genetics
null
unspecified
Large-scale survey
conditional
null
overexpression
Resources
22 total interaction(s) for 21 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 6
  • Affinity Capture-RNA: 1
  • Reconstituted Complex: 1

Genetic Interactions
  • Negative Genetic: 11
  • Phenotypic Suppression: 1
  • Positive Genetic: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 690
Molecular Weight (Da) 76,362
Isoelectric Point (pI) 6.9
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:203039 to 205111 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2073 203039..205111 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002300
SUMMARY PARAGRAPH for BPL1

BPL1 encodes biotin-apoprotein ligase (1), an enzyme that modifies proteins by covalently attaching biotin. Bpl1p is essential (3); among its substrates is Acc1p, acetyl-CoA carboxylase, which acts in fatty acid biosynthesis (3, 2). Bpl1p has strong sequence similarities to biotin--apoprotein ligases from E. coli and human; BPL1 can complement a deletion of E. coli birA (1). Mutations in the human biotin--apoprotein ligase are associated with ataxia and carboxylase deficiency (4).

Last updated: 1999-11-02 Contact SGD

References cited on this page View Complete Literature Guide for BPL1
1) Cronan JE Jr and Wallace JC  (1995) The gene encoding the biotin-apoprotein ligase of Saccharomyces cerevisiae. FEMS Microbiol Lett 130(2-3):221-9
2) Mishina M, et al.  (1980) Yeast mutants defective in acetyl-coenzyme A carboxylase and biotin: apocarboxylase ligase. Eur J Biochem 111(1):79-87
3) Hoja U, et al.  (1998) Pleiotropic phenotype of acetyl-CoA-carboxylase-defective yeast cells--viability of a BPL1-amber mutation depending on its readthrough by normal tRNA(Gln)(CAG). Eur J Biochem 254(3):520-6
4) Foury F  (1997) Human genetic diseases: a cross-talk between man and yeast. Gene 195(1):1-10