BMH2/YDR099W Summary 
BMH2 BASIC INFORMATION
| Standard Name | BMH2 1 |
|---|---|
| Systematic Name | YDR099W |
| Alias | SCD3 |
| Feature Type | ORF, Verified |
| Description | 14-3-3 protein, minor isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling (2, 3 and see Summary Paragraph) 
|
| Name Description | Brain Modulosignalin Homologue 4 |
| GO Annotations | All BMH2 GO evidence and references |
|---|---|
| View Computational GO annotations for BMH2 | |
| Molecular Function | |
| Manually curated | |
| Biological Process | |
| Manually curated |
|
| Cellular Component | |
| Manually curated | |
| High-throughput |
| Mutant Phenotype | All BMH2 Phenotype details and references |
|---|---|
| Classical genetics | |
| null |
|
| overexpression |
|
| Large-scale survey | |
| null |
| Interactions | BMH2 All interactions details and references |
|---|---|
| 174 total interaction(s) for 123 unique genes/features. | |
| Physical Interactions |
|
| Genetic Interactions |
|
| External Links | All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB |
|---|
| Primary SGDID | S000002506 |
|---|
BMH2 RESOURCES
| SGD ORF map | GBrowse |
|---|---|
|
Click on histogram for expression summary
Expression Summary
ADDITIONAL INFORMATION for BMH2
SUMMARY PARAGRAPH for BMH2
BMH2 is one of two genes in yeast that show strong similarity to the ubiquitous and highly conserved 14-3-3 gene family (5, 1). The function of 14-3-3 proteins is not well understood, but they may play a role in signal transduction (6). Although cells lacking BMH2 are viable, a double deletion of both BMH2 and its paralog BMH1 is lethal (5, 1). Cells lacking BMH1 and BMH2 can be rescued by expression of 14-3-3 proteins from Arabidopsis thaliana or Dictyostelium discoideum (7, 8). Bmh1p and Bmh2p are required for Ras/MAPK cascade signaling during pseudohyphal growth, and associate with Ste20p in vivo (9). There is also evidence that Bmh2p may interact with clathrin (Chc1p), suppress mutations in CDC25, interact with Tpk1p, and suppress growth inhibition by rapamycin (10, 5).
Last updated: 1999-09-01
REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for BMH2]
| 1) | van Heusden GP, et al. (1995) The 14-3-3 proteins encoded by the BMH1 and BMH2 genes are essential in the yeast Saccharomyces cerevisiae and can be replaced by a plant homologue. Eur J Biochem 229(1):45-53 |
| 2) | van Hemert MJ, et al. (2001) Yeast 14-3-3 proteins. Yeast 18(10):889-95 |
| 3) | Bruckmann A, et al. (2007) Post-Transcriptional Control of the Saccharomyces cerevisiae Proteome by 14-3-3 Proteins. J Proteome Res 6(5):1689-1699 |
| 4) | van Heusden GP, et al. (1992) Characterization of the yeast BMH1 gene encoding a putative protein homologous to mammalian protein kinase II activators and protein kinase C inhibitors. FEBS Lett 302(2):145-50 |
| 5) | Gelperin D, et al. (1995) 14-3-3 proteins: potential roles in vesicular transport and Ras signaling in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 92(25):11539-43 |
| 6) | Burbelo PD and Hall A (1995) 14-3-3 proteins. Hot numbers in signal transduction. Curr Biol 5(2):95-6 |
| 7) | van Heusden GP, et al. (1996) Four Arabidopsis thaliana 14-3-3 protein isoforms can complement the lethal yeast bmh1 bmh2 double disruption. FEBS Lett 391(3):252-6 |
| 8) | Knetsch ML, et al. (1997) Isolation of a Dictyostelium discoideum 14-3-3 homologue. Biochim Biophys Acta 1357(2):243-8 |
| 9) | Roberts RL, et al. (1997) 14-3-3 proteins are essential for RAS/MAPK cascade signaling during pseudohyphal development in S. cerevisiae. Cell 89(7):1055-65 |
| 10) | Bertram PG, et al. (1998) The 14-3-3 proteins positively regulate rapamycin-sensitive signaling. Curr Biol 8(23):1259-67 |
