Standard Name	BIM1 1
Systematic Name	YER016W
Alias	YEB1
Feature Type	ORF, Verified
Description	Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally (2) Also known as: EB1 3
Name Description	BInding to Microtubules 1

Chromosomal Location	ChrV:188277 to 189311 | ORF Map | GBrowse

	View Computational GO annotations for BIM1
Molecular Function
Manually curated	microtubule plus-end binding (IDA) protein homodimerization activity (IDA) structural constituent of cytoskeleton (IPI)
Biological Process
Manually curated	microtubule depolymerization (IMP) microtubule nucleation (IPI) mitotic sister chromatid cohesion (IGI, IMP) mitotic spindle assembly checkpoint (TAS) negative regulation of microtubule depolymerization (IMP) nuclear migration along microtubule (IMP) positive regulation of microtubule polymerization (IDA)
Cellular Component
Manually curated	cytoplasmic microtubule (IDA) microtubule plus end (IDA) spindle (IDA) spindle midzone (IDA) spindle pole (IDA) spindle pole body (IDA)

Classical genetics
null	chromosome/plasmid maintenance: abnormal chronological lifespan: increased colony sectoring: increased
overexpression	budding index: abnormal cell cycle progression in G2 phase: abnormal
Large-scale survey
null	UV resistance: decreased colony sectoring: increased competitive fitness: decreased resistance to fluconazole: increased resistance to bleomycin: increased resistance to benomyl: decreased resistance to hydroxyurea: decreased resistance to CTBT: decreased resistance to sodium arsenite: decreased resistance to camptothecin: decreased resistance to cycloheximide: decreased resistance to methyl methanesulfonate: decreased resistance to sodium selenide: decreased resistance to edelfosine: decreased resistance to elesclomol-Cu: decreased resistance to sorbate: decreased sporulation: absent viable
overexpression	cell cycle progression: abnormal inviable vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	950 total interaction(s) for 460 unique genes/features.
Physical Interactions	Affinity Capture-MS: 11 Affinity Capture-RNA: 1 Affinity Capture-Western: 11 Biochemical Activity: 1 Co-crystal Structure: 1 Co-fractionation: 2 Co-purification: 1 Reconstituted Complex: 9 Two-hybrid: 35
Genetic Interactions	Dosage Rescue: 5 Negative Genetic: 262 Phenotypic Enhancement: 98 Phenotypic Suppression: 1 Positive Genetic: 26 Synthetic Growth Defect: 153 Synthetic Lethality: 332 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Mass Spec | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrV:188277 to 189311 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1035 188277..189311 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000818