BIG1/YHR101C Summary

BIG1 BASIC INFORMATION

Standard Name	BIG1
Systematic Name	YHR101C
Feature Type	ORF, Verified
Description	Integral membrane protein of the endoplasmic reticulum, required for normal content of cell wall beta-1,6-glucan (1)
Name Description	Bad In Glucose 2

GO Annotations	All BIG1 GO evidence and references
	View Computational GO annotations for BIG1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	fungal-type cell wall biogenesis (IGI, IMP)
Cellular Component
Manually curated	integral to endoplasmic reticulum membrane (IDA)

Mutant Phenotype	All BIG1 Phenotype details and references
Large-scale survey
conditional	heat sensitivity: increased
null	inviable
repressible	cell cycle progression in G2 phase: abnormal

Interactions	BIG1 All interactions details and references
	65 total interaction(s) for 33 unique genes/features.
Physical Interactions	Affinity Capture-Western: 1
Genetic Interactions	Dosage Rescue: 2 Phenotypic Enhancement: 61 Synthetic Rescue: 1

Sequence Information

ChrVIII:315971 to 314877 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2005-11-07 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..110	315971..315862	2005-11-07	1996-07-31
Intron	111..197	315861..315775	2005-11-07	1996-07-31
CDS	198..1095	315774..314877	2005-11-07	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000001143

BIG1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for BIG1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for BIG1]

1)	Azuma M, et al. (2002) Saccharomyces cerevisiae Big1p, a putative endoplasmic reticulum membrane protein required for normal levels of cell wall beta-1,6-glucan. Yeast 19(9):783-93
2)	Bickle M, et al. (1998) Cell wall integrity modulates RHO1 activity via the exchange factor ROM2. EMBO J 17(8):2235-45

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