Standard Name	BFR1 1
Systematic Name	YOR198C
Feature Type	ORF, Verified
Description	Component of mRNP complexes associated with polyribosomes; implicated in secretion and nuclear segregation; multicopy suppressor of BFA (Brefeldin A) sensitivity (1, 2)
Name Description	BreFeldin A Resistance 1

Chromosomal Location	ChrXV:720065 to 718653 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

Molecular Function
Manually curated	RNA binding (IDA)
Biological Process
Manually curated	meiosis (IMP) mRNA metabolic process (IPI) regulation of mitosis (IMP)
Cellular Component
Manually curated	nuclear outer membrane-endoplasmic reticulum membrane network (IDA) polysome (IDA) ribonucleoprotein complex (IDA)

Classical genetics
null	resistance to St. John's Wort extract: decreased
Large-scale survey
null	bud morphology: abnormal cell size: increased glycogen accumulation: increased competitive fitness: decreased dessication resistance: decreased fermentative growth: decreased rate haploinsufficient heat sensitivity: increased resistance to sirolimus: decreased resistance to caffeine: decreased resistance to nickel sulfate: decreased resistance to 1,4-dithiothreitol and tacrolimus (anhydrous): increased resistance to tacrolimus (anhydrous) and tunicamycin: increased resistance to cycloheximide: decreased resistance to amitrole: decreased resistance to sulfometuron methyl: decreased resistance to quinine: decreased resistance to hygromycin B: decreased resistance to spermine: decreased resistance to chloroquine: decreased resistance to wortmannin: normal resistance to St. John's Wort extract: decreased resistance to calcium dichloride: decreased stress resistance: decreased toxin resistance: increased vacuolar morphology: abnormal vegetative growth: decreased rate viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	205 total interaction(s) for 126 unique genes/features.
Physical Interactions	Affinity Capture-MS: 18 Affinity Capture-RNA: 3 Affinity Capture-Western: 8 Biochemical Activity: 3 PCA: 2 Protein-peptide: 1 Reconstituted Complex: 2 Two-hybrid: 15
Genetic Interactions	Dosage Rescue: 2 Negative Genetic: 78 Phenotypic Enhancement: 2 Phenotypic Suppression: 1 Positive Genetic: 62 Synthetic Growth Defect: 6 Synthetic Lethality: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:720065 to 718653 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1413 720065..718653 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005724