SUMMARY PARAGRAPH for BET2
Bet2p,the beta subunit of the type II (RAB-protein) geranylgeranyl transferase (GGTase) (2, 4) forms the catalytic component (component B) along with Bet4 while Mrs6, the accessory subunit, presents the substrate to these catalytic subunits. GGTase II (Bet2, Bet4, Mrs6) is required for transport between the endoplasmic reticulum and the Golgi, and its role in that pathway seems to be in providing a membrane attachment moiety to Ypt1p and Sec4p, small GTP-binding proteins that help mediate vesicular traffic (1, 2, 4). Bet2p shares sequence similarity with Ram1p, the beta subunit of the yeast farnesyl transferase, and with mammalian Rab geranylgeranyl transferase beta subunits (5, 6).
The type II GGTase is one of three prenyl transferases in yeast, the other two being farnesyl transferase and the type I GGTase (7, 4).
Last updated: 2010-05-18