Standard Name	BEM3 1, 2
Systematic Name	YPL115C
Feature Type	ORF, Verified
Description	Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly (1)
Name Description	Bud EMergence 3

Chromosomal Location	ChrXVI:335486 to 332100 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for BEM3
Molecular Function
Manually curated	phosphatidylinositol-3-phosphate binding (IDA) Rho GTPase activator activity (IDA, IGI, IPI)
Biological Process
Manually curated	establishment of cell polarity (TAS) negative regulation of Rho protein signal transduction (IGI, IMP, IPI)
Cellular Component
Manually curated	cell cortex (IDA) cellular bud tip (IDA) cytoplasm (IDA) incipient cellular bud site (IDA) mating projection tip (IDA)
High-throughput	mating projection tip (IDA)

Classical genetics
null	actin cytoskeleton morphology: abnormal bud morphology: abnormal cellular morphology: abnormal Scs2deltaTMD-GFP distribution: abnormal Kss1p modification: increased shmoo formation: abnormal
overexpression	actin cytoskeleton morphology: abnormal bud morphology: abnormal inviable shmoo formation: decreased viable
unspecified	viability: decreased
Large-scale survey
null	UV resistance: decreased competitive fitness: decreased resistance to cycloheximide: decreased resistance to camptothecin: decreased resistance to caffeine: decreased resistance to fenpropimorph: decreased resistance to hydroxyurea: decreased resistance to sirolimus: decreased resistance to bleomycin: decreased starvation resistance: decreased toxin resistance: decreased vacuolar morphology: abnormal viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	113 total interaction(s) for 80 unique genes/features.
Physical Interactions	Affinity Capture-MS: 9 Affinity Capture-RNA: 1 Affinity Capture-Western: 1 Biochemical Activity: 1 PCA: 1 Protein-peptide: 1 Two-hybrid: 13
Genetic Interactions	Dosage Growth Defect: 4 Dosage Rescue: 7 Negative Genetic: 53 Phenotypic Enhancement: 6 Phenotypic Suppression: 2 Positive Genetic: 3 Synthetic Growth Defect: 7 Synthetic Lethality: 2 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXVI:335486 to 332100 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..3387 335486..332100 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000006036