BDF1/YLR399C Summary Help

BDF1 BASIC INFORMATION

Standard Name BDF1
Systematic Name YLR399C
Feature Type ORF, Verified
Description Protein involved in transcription initiation at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf2p (1 and see Summary Paragraph)
Name Description BromoDomain Factor 1, 2
GO Annotations All BDF1 GO evidence and references
    View Computational GO annotations for BDF1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All BDF1 Phenotype details and references
Classical genetics
null
Large-scale survey
null
Interactions BDF1 All interactions details and references
118 total interaction(s) for 83 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 31
  • Affinity Capture-Western: 15
  • Biochemical Activity: 1
  • Reconstituted Complex: 3
  • Two-hybrid: 7
Genetic Interactions
  • Dosage Rescue: 2
  • Phenotypic Enhancement: 8
  • Phenotypic Suppression: 1
  • Synthetic Growth Defect: 31
  • Synthetic Lethality: 19
Sequence Information
ChrXII:921596 to 919536 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
This feature contains embedded feature(s): YLR399W-A
Gbrowse
Last Update Coordinates: 2004-02-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..2061 921596..919536 2004-02-05 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000004391

BDF1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Functional Analysis

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Expression Summary histogram

ADDITIONAL INFORMATION for BDF1

SUMMARY PARAGRAPH for BDF1

BDF1 was identified in a screen for mutants that affect transcription of a reporter snRNA (2). BDF1 mutants show a reduced rate of vegetative growth, sensitivity to DNA damaging agents, and are unable to undergo the meiotic divisions required for sporulation (3). Bdf1p is found in the nucleus throughout the cell cycle, and is localized uniformly along the length of chromosomes (3). This localization suggests that Bdf1p may be a chromatin component (3). Bdf1p has some regions of similarity to proteins from Drosophila and human (2); Bdf1p also contains two "bromodomains," regions that may be involved in interactions with histones (2).

Last updated: 2000-05-01

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for BDF1]

1) Matangkasombut O, et al.  (2000) Bromodomain factor 1 corresponds to a missing piece of yeast TFIID. Genes Dev 14(8):951-62
2) Lygerou Z, et al.  (1994) The yeast BDF1 gene encodes a transcription factor involved in the expression of a broad class of genes including snRNAs. Nucleic Acids Res 22(24):5332-40
3) Chua P and Roeder GS  (1995) Bdf1, a yeast chromosomal protein required for sporulation. Mol Cell Biol 15(7):3685-96