BCS1/YDR375C Summary

BCS1 BASIC INFORMATION

Standard Name	BCS1
Systematic Name	YDR375C
Feature Type	ORF, Verified
Description	Protein of the mitochondrial inner membrane that functions as an ATP-dependent chaperone, required for the incorporation of the Rip1p and Qcr10p subunits into the cytochrome bc(1) complex; member of the CDC48/PAS1/SEC18 ATPase family (1)
Name Description	ubiquinol-cytochrome c reductase (bc1) Synthesis

GO Annotations	All BCS1 GO evidence and references
	View Computational GO annotations for BCS1
Molecular Function
Manually curated	ATPase activity (ISS)
Biological Process
Manually curated	aerobic respiration (IMP) chaperone-mediated protein complex assembly (IMP, IPI) mitochondrion organization (IMP)
Cellular Component
Manually curated	mitochondrial inner membrane (IDA)
High-throughput	mitochondrion (IDA)

Mutant Phenotype	All BCS1 Phenotype details and references
Classical genetics
conditional	Rip1p accumulation: decreased respiratory growth: absent
reduction of function	Rip1p accumulation: decreased respiratory growth: decreased rate respiratory growth: absent
Large-scale survey
null	glycogen accumulation: decreased competitive fitness: decreased resistance to 2-phenyl-3-nitroso-imidazo[1,2-a]pyridine: decreased resistance to ethanol: decreased respiratory growth: decreased rate respiratory growth: absent utilization of carbon source: decreased viable
overexpression	vegetative growth: decreased

Interactions	BCS1 All interactions details and references
	4 total interaction(s) for 4 unique genes/features.
Physical Interactions	Affinity Capture-Western: 4

Sequence Information

ChrIV:1226529 to 1225159 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2008-06-05 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1371	1226529..1225159	2008-06-05	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000002783

BCS1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for BCS1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for BCS1]

1)	Cruciat CM, et al. (1999) Bcs1p, an AAA-family member, is a chaperone for the assembly of the cytochrome bc(1) complex. EMBO J 18(19):5226-33

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