BAT2/YJR148W Summary Help

BAT2 BASIC INFORMATION

Standard Name BAT2 1
Systematic Name YJR148W
Alias TWT2 2 , ECA40 3
Feature Type ORF, Verified
Description Cytosolic branched-chain amino acid aminotransferase, homolog of murine ECA39; highly expressed during stationary phase and repressed during logarithmic phase (3 and see Summary Paragraph)
Name Description Branched-chain Amino acid Transaminase 1
GO Annotations All BAT2 GO evidence and references
    View Computational GO annotations for BAT2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Pathways
Mutant Phenotype All BAT2 Phenotype details and references
Classical genetics
null
Large-scale survey
null
Interactions BAT2 All interactions details and references
25 total interaction(s) for 17 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 9
  • Affinity Capture-RNA: 1
  • Biochemical Activity: 1
  • Two-hybrid: 1
Genetic Interactions
  • Phenotypic Enhancement: 4
  • Synthetic Growth Defect: 1
  • Synthetic Lethality: 8
Sequence Information
ChrX:705734 to 706864 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 2009-02-18 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1131 705734..706864 2009-02-18 1996-07-31
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000003909

BAT2 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Localization Resources
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  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for BAT2

SUMMARY PARAGRAPH for BAT2

BAT1 and BAT2 respectively encode the mitochondrial and cytosolic branched-chain amino acid aminotransferases (BCAATases) (1). BCAATases are required for both branched-chain amino acid biosynthesis and Ehrlich pathway amino acid catabolism; Bat1p and Bat2p catalyze the transfer of amino groups between the amino acids valine, isoleucine, and leucine and their corresponding alpha-keto-acids. Alpha-keto-acids are biosynthetic precursors of fusel alcohols, which influence the aroma and flavor of yeast-derived fermentation products such as beer and bread (4 and references contained therein).

Bat1p and Bat2p are 77% identical to each other and orthologs have been identified in S. pombe, worm, mouse, and human (1, 5). BAT1 is highly expressed during logarithmic phase and repressed during stationary phase, while BAT2 is expressed during stationary phase and repressed during logarithmic growth (3). On glucose-containing media, single deletion of either BAT gene impairs neither cell growth nor fusel alcohol production, but deletion of both genes results in branched-chain amino acid auxotrophy and severe growth retardation (1).

Last updated: 2007-04-30

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for BAT2]

1) Kispal G, et al.  (1996) Mitochondrial and cytosolic branched-chain amino acid transaminases from yeast, homologs of the myc oncogene-regulated Eca39 protein. J Biol Chem 271(40):24458-64
2) Dickinson JR  (2000) Pathways of leucine and valine catabolism in yeast. Methods Enzymol 324:80-92
3) Eden A, et al.  (1996) Two yeast homologs of ECA39, a target for c-Myc regulation, code for cytosolic and mitochondrial branched-chain amino acid aminotransferases. J Biol Chem 271(34):20242-5
4) Lilly M, et al.  (2006) The effect of increased branched-chain amino acid transaminase activity in yeast on the production of higher alcohols and on the flavour profiles of wine and distillates. FEMS Yeast Res 6(5):726-43
5) Eden A and Benvenisty N  (1998) Characterization of a branched-chain amino-acid aminotransferase from Schizosaccharomyces pombe. Yeast 14(2):189-94