BAR1/YIL015W Summary 
BAR1 BASIC INFORMATION
| Standard Name | BAR1 1 |
|---|---|
| Systematic Name | YIL015W |
| Alias | SST1 1 , 2 |
| Feature Type | ORF, Verified |
| Description | Aspartyl protease secreted into the periplasmic space of mating type a cells, helps cells find mating partners, cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest (2, 3, 4 and see Summary Paragraph) 
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| Name Description | BARrier to the alpha factor response 1, 5 |
| GO Annotations | All BAR1 GO evidence and references |
|---|---|
| View Computational GO annotations for BAR1 | |
| Molecular Function | |
| Manually curated | |
| Biological Process | |
| Manually curated | |
| Cellular Component | |
| Manually curated |
| Mutant Phenotype | All BAR1 Phenotype details and references |
|---|---|
| Classical genetics | |
| null | |
| Large-scale survey | |
| null |
|
| Interactions | BAR1 All interactions details and references |
|---|---|
| 3 total interaction(s) for 3 unique genes/features. | |
| Physical Interactions |
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| Genetic Interactions |
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| External Links | All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB |
|---|
| Primary SGDID | S000001277 |
|---|
BAR1 RESOURCES
Click on map for expanded view
| SGD ORF map | GBrowse |
|---|---|
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Click on histogram for expression summary
Expression Summary
ADDITIONAL INFORMATION for BAR1
SUMMARY PARAGRAPH for BAR1
Bar1p is a protease secreted into the periplasmic space of Mata cells that cleaves and inactivates alpha factor (2, 6). Mata cells that lack Bar1p are supersensitive to alpha factor-induced G1 arrest (2, 7). Transcription of BAR1 in alpha haploids and a/alpha diploids is repressed by the alpha2 protein and cofactors, and BAR1 transcription in Mata cells is stimulated by the presence of alpha factor (8, 9, 10). Bar1p is an aspartyl protease with similarity to pepsin, Pep4p, and Yap3p (11, 12, 6).
Last updated: 1999-12-31
REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for BAR1]
| 1) | Sprague GF Jr and Herskowitz I (1981) Control of yeast cell type by the mating type locus. I. Identification and control of expression of the a-specific gene BAR1. J Mol Biol 153(2):305-21 |
| 2) | Chan RK and Otte CA (1982) Physiological characterization of Saccharomyces cerevisiae mutants supersensitive to G1 arrest by a factor and alpha factor pheromones. Mol Cell Biol 2(1):21-9 |
| 3) | Ciejek E and Thorner J (1979) Recovery of S. cerevisiae a cells from G1 arrest by alpha factor pheromone requires endopeptidase action. Cell 18(3):623-35 |
| 4) | Barkai N, et al. (1998) Protease helps yeast find mating partners. Nature 396(6710):422-3 |
| 5) | Hicks JB and Herskowitz I (1976) Evidence for a new diffusible element of mating pheromones in yeast. Nature 260(5548):246-8 |
| 6) | Ballensiefen W and Schmitt HD (1997) Periplasmic Bar1 protease of Saccharomyces cerevisiae is active before reaching its extracellular destination. Eur J Biochem 247(1):142-7 |
| 7) | Chan RK and Otte CA (1982) Isolation and genetic analysis of Saccharomyces cerevisiae mutants supersensitive to G1 arrest by a factor and alpha factor pheromones. Mol Cell Biol 2(1):11-20 |
| 8) | Kronstad JW, et al. (1987) A yeast operator overlaps an upstream activation site. Cell 50(3):369-77 |
| 9) | Manney TR (1983) Expression of the BAR1 gene in Saccharomyces cerevisiae: induction by the alpha mating pheromone of an activity associated with a secreted protein. J Bacteriol 155(1):291-301 |
| 10) | Hagen DC, et al. (1991) Pheromone response elements are necessary and sufficient for basal and pheromone-induced transcription of the FUS1 gene of Saccharomyces cerevisiae. Mol Cell Biol 11(6):2952-61 |
| 11) | MacKay VL, et al. (1988) The Saccharomyces cerevisiae BAR1 gene encodes an exported protein with homology to pepsin. Proc Natl Acad Sci U S A 85(1):55-9 |
| 12) | Egel-Mitani M, et al. (1990) A novel aspartyl protease allowing KEX2-independent MF alpha propheromone processing in yeast. Yeast 6(2):127-37 |
