SPT20/YOL148C Summary Help

Standard Name SPT20
Systematic Name YOL148C
Alias ADA5
Feature Type ORF, Verified
Description Subunit of the SAGA transcriptional regulatory complex; involved in maintaining the integrity of the complex; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay (1, 2)
Name Description SuPpressor of Ty
Chromosomal Location
ChrXV:47574 to 45760 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All SPT20 GO evidence and references
  View Computational GO annotations for SPT20
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Targets 2384 genes
Regulators 82 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
239 total interaction(s) for 83 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 147
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 25
  • Biochemical Activity: 3
  • Co-fractionation: 1
  • Co-localization: 3
  • Co-purification: 7
  • Reconstituted Complex: 8
  • Two-hybrid: 1

Genetic Interactions
  • Phenotypic Enhancement: 3
  • Synthetic Growth Defect: 9
  • Synthetic Lethality: 24
  • Synthetic Rescue: 7

Resources
Expression Summary
histogram
Resources
Length (a.a.) 604
Molecular Weight (Da) 67,796
Isoelectric Point (pI) 10.43
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXV:47574 to 45760 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1815 47574..45760 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005508
References cited on this page View Complete Literature Guide for SPT20
1) Grant PA, et al.  (1998) A subset of TAF(II)s are integral components of the SAGA complex required for nucleosome acetylation and transcriptional stimulation. Cell 94(1):45-53
2) Tous C, et al.  (2011) A novel assay identifies transcript elongation roles for the Nup84 complex and RNA processing factors. EMBO J 30(10):1953-64