AYR1/YIL124W Summary Help

Standard Name AYR1 1
Systematic Name YIL124W
Alias GBG1 2
Feature Type ORF, Verified
Description Bifunctional triacylglycerol lipase and 1-acyl DHAP reductase; NADPH-dependent 1-acyl dihydroxyacetone phosphate reductase involved in phosphatidic acid biosynthesis; lipid droplet triacylglycerol lipase involved in the mobilization of non-polar lipids; found in lipid particles, the endoplasmic reticulum and the mitochondrial outer membrane; required for spore germination; role in cell wall biosynthesis; capable of metabolizing steroid hormones; oleic acid inducible (1, 2, 3, 4, 5)
Name Description 1-AcyldihYdroxyacetone-phosphate Reductase 1
Gene Product Alias 1-acyl dihydroxyacetone phosphate reductase 1
Chromosomal Location
ChrIX:126204 to 127097 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All AYR1 GO evidence and references
  View Computational GO annotations for AYR1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 7 genes
Resources
Pathways
Classical genetics
null
overexpression
Large-scale survey
null
Resources
82 total interaction(s) for 72 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 9
  • Affinity Capture-RNA: 4
  • Co-fractionation: 1
  • PCA: 14
  • Two-hybrid: 1

Genetic Interactions
  • Negative Genetic: 43
  • Positive Genetic: 6
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 1
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 297
Molecular Weight (Da) 32,814
Isoelectric Point (pI) 9.92
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIX:126204 to 127097 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 1994-12-10 | Sequence: 1994-12-10
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..894 126204..127097 1994-12-10 1994-12-10
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001386
References cited on this page View Complete Literature Guide for AYR1
1) Athenstaedt K and Daum G  (2000) 1-Acyldihydroxyacetone-phosphate reductase (Ayr1p) of the yeast Saccharomyces cerevisiae encoded by the open reading frame YIL124w is a major component of lipid particles. J Biol Chem 275(1):235-40
2) Ahn KW, et al.  (2010) Deletion of GBG1/AYR1 Alters Cell Wall Biogenesis in Saccharomyces cerevisiae. Mycobiology 38(2):102-7
3) Vico P, et al.  (2002) Dehydroepiandrosterone (DHEA) metabolism in Saccharomyces cerevisiae expressing mammalian steroid hydroxylase CYP7B: Ayr1p and Fox2p display 17beta-hydroxysteroid dehydrogenase activity. Yeast 19(10):873-86
4) Zahedi RP, et al.  (2006) Proteomic analysis of the yeast mitochondrial outer membrane reveals accumulation of a subclass of preproteins. Mol Biol Cell 17(3):1436-50
5) Ploier B, et al.  (2013) Screening for Hydrolytic Enzymes Reveals Ayr1p as a Novel Triacylglycerol Lipase in Saccharomyces cerevisiae. J Biol Chem 288(50):36061-72