AXL2/YIL140W Summary Help

Standard Name AXL2
Systematic Name YIL140W
Alias BUD10 , SRO4
Feature Type ORF, Verified
Description Integral plasma membrane protein; required for axial budding in haploid cells; localizes to the incipient bud site and bud neck; glycosylated by Pmt4p; potential Cdc28p substrate (1, 2, 3)
Name Description AXiaL budding pattern
Chromosomal Location
ChrIX:85366 to 87837 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All AXL2 GO evidence and references
  View Computational GO annotations for AXL2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 5 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
Resources
55 total interaction(s) for 38 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 4
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 9
  • Biochemical Activity: 1
  • PCA: 3
  • Reconstituted Complex: 1

Genetic Interactions
  • Dosage Growth Defect: 2
  • Dosage Lethality: 1
  • Dosage Rescue: 8
  • Negative Genetic: 19
  • Phenotypic Enhancement: 2
  • Phenotypic Suppression: 1
  • Synthetic Growth Defect: 2
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 823
Molecular Weight (Da) 90,782
Isoelectric Point (pI) 4.68
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIX:85366 to 87837 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 1994-12-10 | Sequence: 1994-12-10
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2472 85366..87837 1994-12-10 1994-12-10
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001402
References cited on this page View Complete Literature Guide for AXL2
1) Roemer T, et al.  (1996) Selection of axial growth sites in yeast requires Axl2p, a novel plasma membrane glycoprotein. Genes Dev 10(7):777-93
2) Sanders SL, et al.  (1999) O-Glycosylation of Axl2/Bud10p by Pmt4p is required for its stability, localization, and function in daughter cells. J Cell Biol 145(6):1177-88
3) Ubersax JA, et al.  (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64