Standard Name	AXL1 1
Systematic Name	YPR122W
Alias	FUS5 2 , STE22 3
Feature Type	ORF, Verified
Description	Haploid specific endoprotease that performs one of two N-terminal cleavages during maturation of a-factor mating pheromone; required for axial budding pattern of haploid cells (1, 3, 4, 5)
Name Description	AXiaL budding 1

Chromosomal Location	ChrXVI:782045 to 785671 | ORF Map | GBrowse

	View Computational GO annotations for AXL1
Molecular Function
Manually curated	metalloendopeptidase activity (IMP, ISS)
Biological Process
Manually curated	axial cellular bud site selection (IMP) peptide pheromone maturation (IGI, IMP, ISS)
Cellular Component
Manually curated	cellular bud neck (IDA) mating projection tip (IDA)

Classical genetics
null	axial budding pattern: decreased bipolar budding pattern: increased cell fusion: decreased invasive growth: increased mating efficiency: decreased mating response: decreased Mfa1p secretion: decreased Mfa1p propheromone, P2 intermediate accumulation: increased
reduction of function	cell fusion: absent mating efficiency: decreased
Large-scale survey
null	competitive fitness: increased hyperosmotic stress resistance: decreased resistance to methyl methanesulfonate: decreased resistance to benzo[a]pyrene: increased resistance to benzo[a]pyrene: decreased resistance to ethanol: decreased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	56 total interaction(s) for 53 unique genes/features.
Physical Interactions	Affinity Capture-MS: 2 Affinity Capture-Western: 5
Genetic Interactions	Dosage Rescue: 1 Negative Genetic: 41 Phenotypic Enhancement: 3 Phenotypic Suppression: 1 Positive Genetic: 1 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXVI:782045 to 785671 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..3627 782045..785671 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000006326