AVO2/YMR068W Summary 
| Standard Name | AVO2 |
|---|---|
| Systematic Name | YMR068W |
| Feature Type | ORF, Verified |
| Description | Component of a complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth (1 and see Summary Paragraph) |
| Name Description | Adheres VOraciously (to TOR2) |
| Chromosomal Location | |
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Gene Ontology Annotations All AVO2 GO evidence and references
| View Computational GO annotations for AVO2 | |
| Molecular Function | |
| Manually curated |
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| Biological Process | |
| Manually curated | |
| Cellular Component | |
| Manually curated | |
| High-throughput |
Mutant phenotypes All AVO2 Phenotype evidence and references
| Classical genetics | |
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| overexpression | |
| Large-scale survey | |
| null |
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| overexpression | |
| Resources |
interactions All AVO2 Interaction evidence and references
| 75 total interaction(s) for 49 unique genes/features. | |
| Physical Interactions |
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| Genetic Interactions |
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| Resources |
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Expression Summary
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| Resources |
Protein Information All AVO2 Protein evidence and references
| Localization | |
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| Phosphorylation | PhosphoGRID | PhosphoPep Database |
| Structure | |
| Homologs |
sequence information
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| Last Update | Coordinates: 2011-02-03 | Sequence: 1996-07-31 | ||||||||||||
| Subfeature details |
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| Retrieve sequences | |||||||||||||
Analyze Sequence
| S288C only | |
|---|---|
| S288C vs. other species | |
| S288C vs. other strains |
Resources
| External Links | All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB |
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| Primary SGDID | S000004672 |
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SUMMARY PARAGRAPH for AVO2
AVO2 encodes a nonessential protein that is a subunit of the TOR complex 2 (TORC2) (2). TORC2 is involved in regulating actin cytoskeleton polarization during cell cycle progression, cell wall integrity, and nutrient receptor endocytosis (3, 4). In addition to Avo2p, TORC2 contains Avo1p, Tsc11, Lst8p, Bit61p, Slm1p, Slm2p, and Tor2p (1, 5, 6). Through direct physical interaction with Avo2p and Bit61p, the subunits Slm1p and Slm2p are able to associate with TORC2 (6). TORC2 is structurally conserved in higher eukaryotes and, like yeast TORC2, functions to regulate the actin cytoskeleton (1, 7).
Last updated: 2005-11-08 
References cited on this page View Complete Literature Guide for AVO2
| 1) | Loewith R, et al. (2002) Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Mol Cell 10(3):457-68 |
| 2) | Wullschleger S, et al. (2005) Molecular organization of target of rapamycin complex 2. J Biol Chem 280(35):30697-704 |
| 3) | Schmidt A, et al. (1996) TOR2 is required for organization of the actin cytoskeleton in yeast. Proc Natl Acad Sci U S A 93(24):13780-5 |
| 4) | deHart AK, et al. (2003) Receptor internalization in yeast requires the Tor2-Rho1 signaling pathway. Mol Biol Cell 14(11):4676-84 |
| 5) | Reinke A, et al. (2004) TOR complex 1 includes a novel component, Tco89p (YPL180w), and cooperates with Ssd1p to maintain cellular integrity in Saccharomyces cerevisiae. J Biol Chem 279(15):14752-62 |
| 6) | Fadri M, et al. (2005) The pleckstrin homology domain proteins Slm1 and Slm2 are required for actin cytoskeleton organization in yeast and bind phosphatidylinositol-4,5-bisphosphate and TORC2. Mol Biol Cell 16(4):1883-900 |
| 7) | Jacinto E, et al. (2004) Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat Cell Biol 6(11):1122-8 |
