AVL9/YLR114C Summary Help

Standard Name AVL9 1
Systematic Name YLR114C
Feature Type ORF, Verified
Description Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress (1, 2)
Name Description Apl2 Vps1 Lethal 1
Chromosomal Location
ChrXII:377238 to 374944 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All AVL9 GO evidence and references
  View Computational GO annotations for AVL9
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 5 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
172 total interaction(s) for 121 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Lethality: 1
  • Negative Genetic: 140
  • Positive Genetic: 23
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 4

Resources
Expression Summary
histogram
Resources
Length (a.a.) 764
Molecular Weight (Da) 86,425
Isoelectric Point (pI) 4.18
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXII:377238 to 374944 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2295 377238..374944 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004104
References cited on this page View Complete Literature Guide for AVL9
1) Harsay E and Schekman R  (2007) Avl9p, a member of a novel protein superfamily, functions in the late secretory pathway. Mol Biol Cell 18(4):1203-19
2) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76