SUMMARY PARAGRAPH for ATP6
ATP6 is one of three mitochondrial genes, along with ATP8 and OLI1, that encode ATP synthase subunits. Also known as subunit 6 or Y6, Atp6p is homologous to subunit a of bacterial ATP synthase (4 and references therein). The ATP synthase complex utilizes proton motive force to generate ATP from ADP and Pi (5). The structure of this enzyme complex is highly conserved among diverse organisms and consists of two major components, soluble F1 and membrane-bound F0, each of which contains many subunits. Y6 is a component of F0. It is hypothesized that Y6, an integral membrane protein, provides a stationary structure necessary for the productive rotation of Y9 (Oli1p) subunits and the resulting coupling of proton motive force to ATP synthesis.(5, 6).
Although ATP6 is essential for ATP synthase function, it is not essential for life in yeast. Deletion of ATP6, like deletions in many genes necessary for the function or maintenance of mitochondria, leads to a "petite" phenotype that is slow-growing and unable to survive on nonfermentable carbon sources (7).
General ATP synthase structure and function are reviewed in references 5 and 6. For a review that is specific to yeast, see reference 4.
Last updated: 2006-04-03