ATP3/YBR039W Summary Help

ATP3 BASIC INFORMATION

Standard Name ATP3
Systematic Name YBR039W
Feature Type ORF, Verified
Description Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis (1 and see Summary Paragraph)
Name Description ATP synthase
GO Annotations All ATP3 GO evidence and references
    View Computational GO annotations for ATP3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Mutant Phenotype All ATP3 Phenotype details and references
Classical genetics
gain of function
reduction of function
Large-scale survey
null
Interactions ATP3 All interactions details and references
33 total interaction(s) for 29 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 24
  • Affinity Capture-RNA: 1
  • Co-purification: 4
Genetic Interactions
  • Synthetic Growth Defect: 1
  • Synthetic Rescue: 3
Sequence Information
ChrII:315575 to 316510 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 2004-07-16 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..936 315575..316510 2004-07-16 1997-01-28
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000000243

ATP3 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Localization Resources
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  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for ATP3

SUMMARY PARAGRAPH for ATP3

ATP3 encodes the gamma subunit of mitochondrial F1-ATP synthase complex (1). The F0-F1ATP synthase complex utilizes proton motive force for ATP hydrolysis/synthesis (2). The structure of this enzyme complex is highly conserved among diverse organisms and consists of two major components, soluble F1 and membrane-bound F0, each of which contains many subunits. F1 and F0 are connected, both functionally and physically, via two additional multi-subunit structures, the central stalk and the stator stalk. The gamma subunit is a component of the central stalk. The central stalk functions like a rotor shaft to transmit the movement of the F0 proton pump to the catalytic core of F1. Although the gamma subunit is not specifically required for F1 ATPase activity, it is essential for enzyme complex cooperativity (2 and 3 and references therein).

ATP3 is essential for ATP synthase function, but it is not essential for life in yeast. Deletion of ATP3, like deletions in many genes necessary for the function or maintenance of mitochondria, leads to a "petite" phenotype that is slow-growing and unable to survive on nonfermentable carbon sources (1).

General ATP synthase structure and function are reviewed in references 2 and 3. For a review that is specific to yeast, see reference 4.

Last updated: 2001-01-11

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for ATP3]

1) Paul MF, et al.  (1994) Cloning of the yeast ATP3 gene coding for the gamma-subunit of F1 and characterization of atp3 mutants. J Biol Chem 269(42):26158-64
2) Boyer PD  (1997) The ATP synthase--a splendid molecular machine. Annu Rev Biochem 66:717-49
3) Nakamoto RK, et al.  (1999) Rotational coupling in the F0F1 ATP synthase. Annu Rev Biophys Biomol Struct 28:205-34
4) Devenish RJ, et al.  (2000) Insights into ATP synthase assembly and function through the molecular genetic manipulation of subunits of the yeast mitochondrial enzyme complex. Biochim Biophys Acta 1458(2-3):428-42