ATP19/YOL077W-A Summary Help

Standard Name ATP19
Systematic Name YOL077W-A
Feature Type ORF, Verified
Description Subunit k of the mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; associated only with the dimeric form of ATP synthase (1 and see Summary Paragraph)
Name Description ATP synthase
Chromosomal Location
ChrXV:185438 to 185644 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All ATP19 GO evidence and references
  View Computational GO annotations for ATP19
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 4 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
Resources
11 total interaction(s) for 11 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-RNA: 2

Genetic Interactions
  • Negative Genetic: 8

Resources
Expression Summary
histogram
Resources
Length (a.a.) 68
Molecular Weight (Da) 7,534
Isoelectric Point (pI) 9.8
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXV:185438 to 185644 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2006-01-05 | Sequence: 1999-07-17
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..207 185438..185644 2006-01-05 1999-07-17
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000007339
SUMMARY PARAGRAPH for ATP19

ATP19 encodes subunit k of yeast mitochondrial ATP synthase (1). The ATP synthase complex utilizes proton motive force to generate ATP from ADP and Pi (2). The structure of this enzyme complex is highly conserved among diverse organisms and consists of two major components, soluble F1 and membrane-bound F0, each of which contains many subunits. Subunit k is one of only a few known ATP synthase subunits that are unique to yeast mitochondria; no subunit k homologs have been identified in either mammalian mitochondria or bacteria (3). Although subunit k is associated with dimerized ATP synthase complexes, its specific function is unknown. Deletion of ATP19 has no affect on ATP synthase function, assembly or dimerization (1).

General ATP synthase structure and function are reviewed in references 2 and 4. For a review that is specific to yeast, see reference 3.

Last updated: 2001-01-17 Contact SGD

References cited on this page View Complete Literature Guide for ATP19
1) Arnold I, et al.  (1998) Yeast mitochondrial F1F0-ATP synthase exists as a dimer: identification of three dimer-specific subunits. EMBO J 17(24):7170-8
2) Boyer PD  (1997) The ATP synthase--a splendid molecular machine. Annu Rev Biochem 66:717-49
3) Devenish RJ, et al.  (2000) Insights into ATP synthase assembly and function through the molecular genetic manipulation of subunits of the yeast mitochondrial enzyme complex. Biochim Biophys Acta 1458(2-3):428-42
4) Nakamoto RK, et al.  (1999) Rotational coupling in the F0F1 ATP synthase. Annu Rev Biophys Biomol Struct 28():205-34