ATP18/YML081C-A Summary Help

Standard Name ATP18
Systematic Name YML081C-A
Feature Type ORF, Verified
Description Subunit of the mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; termed subunit I or subunit j; does not correspond to known ATP synthase subunits in other organisms (1, 2 and see Summary Paragraph)
Name Description ATP synthase
Chromosomal Location
ChrXIII:104162 to 103983 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gene Ontology Annotations All ATP18 GO evidence and references
  View Computational GO annotations for ATP18
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 7 genes
Classical genetics
Large-scale survey
169 total interaction(s) for 122 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 5
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 3
  • Co-purification: 3
  • Reconstituted Complex: 3

Genetic Interactions
  • Negative Genetic: 127
  • Positive Genetic: 25
  • Synthetic Growth Defect: 1

Expression Summary
Length (a.a.) 59
Molecular Weight (Da) 6,688
Isoelectric Point (pI) 10.54
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrXIII:104162 to 103983 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Last Update Coordinates: 1997-07-17 | Sequence: 1997-07-17
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..180 104162..103983 1997-07-17 1997-07-17
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000007247

ATP18 encodes subunit i/j of yeast mitochondrial ATP synthase (2, 1). The ATP synthase complex utilizes proton motive force to generate ATP from ADP and Pi (3). The structure of this enzyme complex is highly conserved among diverse organisms and consists of two major components, soluble F1 and membrane-bound F0, each of which contains many subunits. Subunit i/j is one of only a few known ATP synthase subunits that are unique to yeast mitochondria; no subunit i/j homologs have been identified in either mammalian mitochondria or bacteria. The specific function of this protein is not yet known and reports on the consequence of ATP18 deletions have been mixed (4 and references therein).

General ATP synthase structure and function are reviewed in references 3 and 5. For a review that is specific to yeast, see reference (4).

Last updated: 2001-01-17 Contact SGD

References cited on this page View Complete Literature Guide for ATP18
1) Arnold I, et al.  (1999) ATP synthase of yeast mitochondria. Isolation of subunit j and disruption of the ATP18 gene. J Biol Chem 274(1):36-40
2) Vaillier J, et al.  (1999) Isolation of supernumerary yeast ATP synthase subunits e and i. Characterization of subunit i and disruption of its structural gene ATP18. J Biol Chem 274(1):543-8
3) Boyer PD  (1997) The ATP synthase--a splendid molecular machine. Annu Rev Biochem 66:717-49
4) Devenish RJ, et al.  (2000) Insights into ATP synthase assembly and function through the molecular genetic manipulation of subunits of the yeast mitochondrial enzyme complex. Biochim Biophys Acta 1458(2-3):428-42
5) Nakamoto RK, et al.  (1999) Rotational coupling in the F0F1 ATP synthase. Annu Rev Biophys Biomol Struct 28():205-34