ATP17/YDR377W Summary Help

Standard Name ATP17
Systematic Name YDR377W
Feature Type ORF, Verified
Description Subunit f of the F0 sector of mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis (1 and see Summary Paragraph)
Name Description ATP synthase
Chromosomal Location
ChrIV:1228611 to 1228916 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All ATP17 GO evidence and references
  View Computational GO annotations for ATP17
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 1 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
53 total interaction(s) for 45 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 1
  • Co-purification: 5
  • Protein-peptide: 2
  • Reconstituted Complex: 4

Genetic Interactions
  • Negative Genetic: 20
  • Phenotypic Suppression: 2
  • Positive Genetic: 10
  • Synthetic Growth Defect: 3
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 101
Molecular Weight (Da) 11,312
Isoelectric Point (pI) 10.95
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:1228611 to 1228916 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..306 1228611..1228916 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002785
SUMMARY PARAGRAPH for ATP17

ATP17 encodes subunit f of mitochondrial ATP synthase (1). The ATP synthase complex utilizes proton motive force to generate ATP from ADP and Pi (2). The structure of this enzyme complex is highly conserved among diverse organisms and consists of two major components, soluble F1 and membrane-bound F0, each of which contains many subunits. Atp17p is homologous to mammalian mitochondrial subunit f, but has no bacterial homolog. Although the specific function of this integral membrane protein is not yet known, it is essential for ATP synthase activity (3 and references therein). Deletion of ATP17, like deletions in many genes necessary for the function or maintenance of mitochondria, leads to a "petite" phenotype that is slow-growing and unable to survive on nonfermentable carbon sources (1).

General ATP synthase structure and function are reviewed in references 2) and 4. For a review that is specific to yeast, see reference 3.

Last updated: 2001-01-17 Contact SGD

References cited on this page View Complete Literature Guide for ATP17
1) Spannagel C, et al.  (1997) The subunit f of mitochondrial yeast ATP synthase--characterization of the protein and disruption of the structural gene ATP17. Eur J Biochem 247(3):1111-7
2) Boyer PD  (1997) The ATP synthase--a splendid molecular machine. Annu Rev Biochem 66:717-49
3) Devenish RJ, et al.  (2000) Insights into ATP synthase assembly and function through the molecular genetic manipulation of subunits of the yeast mitochondrial enzyme complex. Biochim Biophys Acta 1458(2-3):428-42
4) Nakamoto RK, et al.  (1999) Rotational coupling in the F0F1 ATP synthase. Annu Rev Biophys Biomol Struct 28():205-34