ATP16/YDL004W Summary Help

ATP16 BASIC INFORMATION

Standard Name ATP16
Systematic Name YDL004W
Feature Type ORF, Verified
Description Delta subunit of the central stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated (1, 2 and see Summary Paragraph)
Name Description ATP synthase
GO Annotations All ATP16 GO evidence and references
    View Computational GO annotations for ATP16
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Mutant Phenotype All ATP16 Phenotype details and references
Classical genetics
null
Large-scale survey
null
Interactions ATP16 All interactions details and references
8 total interaction(s) for 6 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2
  • Affinity Capture-RNA: 1
  • Biochemical Activity: 1
  • Co-purification: 4
Sequence Information
ChrIV:443027 to 443509 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 2008-06-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..483 443027..443509 2008-06-05 1996-07-31
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000002162

ATP16 RESOURCES

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Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for ATP16

SUMMARY PARAGRAPH for ATP16

ATP16 encodes the delta subunit of mitochondrial ATP synthase and is homologous to the epsilon subunit of bacterial ATP synthase (1). The ATP synthase complex utilizes proton motive force to generate ATP from ADP and Pi (3). The structure of this enzyme complex is highly conserved among diverse organisms and consists of two major components, soluble F1 and membrane-bound F0, each of which contains many subunits. F1 and F0 are connected, both functionally and physically, via two additional multi-subunit structures, the central stalk and the stator stalk. The delta subunit is part of the central stalk, which, like a rotor shaft, transmits the movement of the F0 proton pump to the catalytic core of F1 (4 and references therein).

Although ATP16 is essential for ATP synthase function, it is not essential for life in yeast. Deletion of ATP16, like deletions in many genes necessary for the function or maintenance of mitochondria, leads to a "petite" phenotype that is slow-growing and unable to survive on nonfermentable carbon sources (1).

General ATP synthase structure and function are reviewed in references 3 and 4. For a review that is specific to yeast, see reference 5.

Last updated: 2001-01-16

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for ATP16]

1) Giraud MF and Velours J  (1994) ATP synthase of yeast mitochondria. Isolation of the F1 delta subunit, sequence and disruption of the structural gene. Eur J Biochem 222(3):851-9
2) Reinders J, et al.  (2007) Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase. Mol Cell Proteomics 6(11):1896-906
3) Boyer PD  (1997) The ATP synthase--a splendid molecular machine. Annu Rev Biochem 66:717-49
4) Nakamoto RK, et al.  (1999) Rotational coupling in the F0F1 ATP synthase. Annu Rev Biophys Biomol Struct 28:205-34
5) Devenish RJ, et al.  (2000) Insights into ATP synthase assembly and function through the molecular genetic manipulation of subunits of the yeast mitochondrial enzyme complex. Biochim Biophys Acta 1458(2-3):428-42