SUMMARY PARAGRAPH for ATP14
ATP14 encodes subunit h of yeast mitochondrial ATP synthase (1). The ATP synthase complex utilizes proton motive force to generate ATP from ADP and Pi (3). The structure of this enzyme complex is highly conserved among diverse organisms and consists of two major components, soluble F1 and membrane-bound F0, each of which contains many subunits. Subunit h is one of only a few known ATP synthase subunits that are unique to yeast mitochondria; no subunit h homologs have been identified in either mammalian mitochondria or bacteria. Although the specific function of this protein is not yet known, it is essential for F0 assembly and ATP synthase activity (4 and references therein). Its N-terminal 32 amino acids are removed during import into mitochondria (5). Deletion of ATP14, like deletions in many genes necessary for the function or maintenance of mitochondria, leads to a "petite" phenotyepe that is slow-growing and unable to survive on nonfermentable carbon sources (1).
General ATP synthase structure and function are reviewed in references 3 and 6. For a review that is specific to yeast, see reference 4.
Last updated: 2007-10-23