ARV1/YLR242C Summary

ARV1 BASIC INFORMATION

Standard Name	ARV1 1
Systematic Name	YLR242C
Feature Type	ORF, Verified
Description	Protein functioning in transport of glycosylphosphatidylinositol intermediates into the ER lumen; required for normal intracellular sterol distribution and for sphingolipid metabolism; similar to Nup120p and C. elegans R05H5.5 protein (1, 2, 3)
Name Description	ARE2 Required for Viability 1

GO Annotations	All ARV1 GO evidence and references
	View Computational GO annotations for ARV1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	intracellular sterol transport (IMP) sphingolipid metabolic process (IMP) sterol metabolic process (ISS)
Cellular Component
Manually curated	endoplasmic reticulum (IDA) Golgi apparatus (IDA) integral to membrane (ISS)

Mutant Phenotype	All ARV1 Phenotype details and references
Classical genetics
null	ergosterol accumulation: increased endocytosis: decreased heat sensitivity: increased resistance to nystatin: decreased vacuolar morphology: abnormal
Large-scale survey
null	alkaline pH resistance: decreased glycogen accumulation: increased competitive fitness: decreased fermentative growth: decreased rate resistance to rapamycin: decreased resistance to wortmannin: normal resistance to L-1,4-dithiothreitol: decreased resistance to miconazole: decreased resistance to amiodarone: decreased resistance to lovastatin: decreased resistance to nickel sulfate: increased telomere length: decreased transposable element transposition: decreased vegetative growth: absent viable
overexpression	resistance to rapamycin: decreased

Interactions	ARV1 All interactions details and references
	122 total interaction(s) for 68 unique genes/features.
Physical Interactions	Biochemical Activity: 3 PCA: 1 Two-hybrid: 3
Genetic Interactions	Dosage Rescue: 5 Phenotypic Enhancement: 76 Phenotypic Suppression: 26 Synthetic Growth Defect: 3 Synthetic Lethality: 5

Sequence Information

ChrXII:623885 to 622920 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2004-02-05 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..966	623885..622920	2004-02-05	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000004232

ARV1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for ARV1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for ARV1]

1)	Tinkelenberg AH, et al. (2000) Mutations in yeast ARV1 alter intracellular sterol distribution and are complemented by human ARV1. J Biol Chem 275(52):40667-70
2)	Swain E, et al. (2002) Yeast cells lacking the ARV1 gene harbor defects in sphingolipid metabolism. Complementation by human ARV1. J Biol Chem 277(39):36152-60
3)	Kajiwara K, et al. (2008) Yeast ARV1 Is Required for Efficient Delivery of an Early GPI Intermediate to the First Mannosyltransferase during GPI Assembly and Controls Lipid Flow from the Endoplasmic Reticulum. Mol Biol Cell 19(5):2069-82

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