Standard Name	ARP6 1
Systematic Name	YLR085C
Feature Type	ORF, Verified
Description	Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A (1, 2)
Name Description	Actin-Related Protein 1

Chromosomal Location	ChrXII:301989 to 300673 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for ARP6
Molecular Function
Manually curated	nucleosome binding (IMP)
Biological Process
Manually curated	chromatin remodeling (IDA, IMP) histone exchange (IMP)
High-throughput	chromatin remodeling (IGI)
Cellular Component
Manually curated	cytoplasm (IDA) Swr1 complex (IDA)

Classical genetics
null	actin cytoskeleton morphology: abnormal chromosome/plasmid maintenance: abnormal resistance to methyl methanesulfonate: decreased resistance to tellurite: increased vacuolar morphology: abnormal
Large-scale survey
null	competitive fitness: decreased dessication resistance: decreased haploproficient metal resistance: decreased protein transport: abnormal resistance to oleate: decreased resistance to wortmannin: decreased resistance to sirolimus: decreased resistance to cycloheximide: decreased resistance to amitrole: decreased resistance to streptomycin: decreased resistance to caffeine: decreased resistance to sodium arsenite: decreased resistance to neothyonidioside: decreased resistance to hygromycin B: decreased resistance to spermine: decreased resistance to sodium selenide: decreased resistance to dimethyl sulfoxide: decreased resistance to flubendazole: decreased resistance to BPS: decreased resistance to benomyl: decreased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	699 total interaction(s) for 342 unique genes/features.
Physical Interactions	Affinity Capture-MS: 31 Affinity Capture-RNA: 1 Affinity Capture-Western: 5 Co-fractionation: 1 Co-localization: 1
Genetic Interactions	Negative Genetic: 343 Phenotypic Enhancement: 34 Phenotypic Suppression: 19 Positive Genetic: 36 Synthetic Growth Defect: 133 Synthetic Lethality: 88 Synthetic Rescue: 7
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXII:301989 to 300673 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1317 301989..300673 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004075