ARP4/YJL081C Summary

ARP4 BASIC INFORMATION

Standard Name	ARP4 1
Systematic Name	YJL081C
Alias	ACT3 2
Feature Type	ORF, Verified
Description	Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes (1, 2, 3, 4)
Name Description	Actin-Related Protein

GO Annotations	All ARP4 GO evidence and references
	View Computational GO annotations for ARP4
Molecular Function
Manually curated	contributes_to ATP-dependent 3'-5' DNA helicase activity (IDA) chromatin binding (IDA) contributes_to histone acetyltransferase activity (IMP)
Biological Process
Manually curated	chromatin organization (IMP, IPI) chromatin remodeling (IDA) DNA repair (IDA, IMP) histone acetylation (IDA) kinetochore assembly (IMP) regulation of cellular transcription, DNA-dependent (IMP) regulation of transcription from RNA polymerase II promoter (IDA)
Cellular Component
Manually curated	Ino80 complex (IPI) NuA4 histone acetyltransferase complex (IPI) nuclear chromatin (IDA) nucleus (IDA) Swr1 complex (IDA)

Mutant Phenotype	All ARP4 Phenotype details and references
Classical genetics
conditional	cell cycle progression in metaphase: arrested cell cycle progression through the G1/S phase transition: delayed heat sensitivity: increased nuclear morphology: abnormal resistance to hydroxyurea: decreased resistance to benomyl: decreased spindle morphology: abnormal
reduction of function	heat sensitivity: increased resistance to rapamycin: decreased resistance to methyl methanesulfonate: decreased resistance to hydroxyurea: decreased survival rate in stationary phase: decreased viability: decreased
Large-scale survey
null	inviable

Interactions	ARP4 All interactions details and references
	415 total interaction(s) for 251 unique genes/features.
Physical Interactions	Affinity Capture-MS: 119 Affinity Capture-RNA: 1 Affinity Capture-Western: 23 Co-purification: 1 Far Western: 4 Reconstituted Complex: 3 Two-hybrid: 5
Genetic Interactions	Dosage Rescue: 2 Phenotypic Enhancement: 30 Phenotypic Suppression: 1 Synthetic Growth Defect: 158 Synthetic Lethality: 65 Synthetic Rescue: 3

Sequence Information

ChrX:285265 to 283796 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2009-02-18 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1470	285265..283796	2009-02-18	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000003617

ARP4 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for ARP4

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for ARP4]

1)	Poch O and Winsor B (1997) Who's who among the Saccharomyces cerevisiae actin-related proteins? A classification and nomenclature proposal for a large family. Yeast 13(11):1053-8
2)	Harata M, et al. (1994) An essential gene of Saccharomyces cerevisiae coding for an actin-related protein. Proc Natl Acad Sci U S A 91(17):8258-62
3)	Harata M, et al. (1999) The nuclear actin-related protein of Saccharomyces cerevisiae, Act3p/Arp4, interacts with core histones. Mol Biol Cell 10(8):2595-605
4)	Shen X, et al. (2003) Involvement of actin-related proteins in ATP-dependent chromatin remodeling. Mol Cell 12(1):147-55

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