ARO1/YDR127W Summary

ARO1 BASIC INFORMATION

Standard Name	ARO1
Systematic Name	YDR127W
Feature Type	ORF, Verified
Description	Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids (1, 2)
Name Description	AROmatic amino acid requiring

GO Annotations	All ARO1 GO evidence and references
	View Computational GO annotations for ARO1
Molecular Function
Manually curated	3-dehydroquinate dehydratase activity (IDA) 3-dehydroquinate synthase activity (IDA) 3-phosphoshikimate 1-carboxyvinyltransferase activity (IDA) shikimate 5-dehydrogenase activity (IDA) shikimate kinase activity (IDA)
Biological Process
Manually curated	aromatic amino acid family biosynthetic process (TAS)
Cellular Component
High-throughput	cytoplasm (IDA)

Pathways	chorismate biosynthesis pathways of chorismate superpathway of phenylalanine, tyrosine and tryptophan biosynthesis

Mutant Phenotype	All ARO1 Phenotype details and references
Classical genetics
null	resistance to 2-phenylethanol: decreased
Large-scale survey
null	alkaline pH resistance: decreased polyphosphate accumulation: abnormal heat sensitivity: increased hyperosmotic stress resistance: decreased resistance to miconazole: decreased resistance to sulfanilamide: decreased resistance to ethanol: decreased resistance to methyl methanesulfonate: decreased resistance to propan-1-ol: decreased toxin resistance: decreased viable

Interactions	ARO1 All interactions details and references
	152 total interaction(s) for 137 unique genes/features.
Physical Interactions	Affinity Capture-MS: 48 Two-hybrid: 1
Genetic Interactions	Phenotypic Enhancement: 60 Phenotypic Suppression: 38 Synthetic Lethality: 5

Sequence Information

ChrIV:704482 to 709248 | |

Genetic position: 81 cM

Last Update

Coordinates: 2008-06-05 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..4767	704482..709248	2008-06-05	1996-07-31

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000002534

ARO1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for ARO1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for ARO1]

1)	Duncan K, et al. (1987) The pentafunctional arom enzyme of Saccharomyces cerevisiae is a mosaic of monofunctional domains. Biochem J 246(2):375-86
2)	Jones EW and Fink GR (1982) "Regulation of amino acid and nucleotide biosynthesis in yeast." Pp.181-299 in The Molecular Biology of the Yeast Saccharomyces: Metabolism and Gene Expression, edited by Strathern JN, Jones EW and Broach JR. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press

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