ARL3/YPL051W Summary Help

Standard Name ARL3 1
Systematic Name YPL051W
Feature Type ORF, Verified
Description ARF-like small GTPase of the RAS superfamily; required for recruitment of Arl1p, a GTPase that regulates membrane traffic, to the Golgi apparatus; NatC-catalyzed N-terminal acetylation regulates Golgi membrane association mediated by interaction with membrane receptor, Sys1p; similar to ADP-ribosylation factor and orthologous to mammalian ARFRP1 (1, 2, 3)
Name Description ADP-Ribosylation factor-Like 1
Chromosomal Location
ChrXVI:459963 to 460559 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All ARL3 GO evidence and references
  View Computational GO annotations for ARL3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 2 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
435 total interaction(s) for 229 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 7
  • Affinity Capture-RNA: 3
  • Affinity Capture-Western: 2
  • Co-localization: 1

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 338
  • Phenotypic Enhancement: 1
  • Positive Genetic: 33
  • Synthetic Growth Defect: 25
  • Synthetic Lethality: 22
  • Synthetic Rescue: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 198
Molecular Weight (Da) 22,782
Isoelectric Point (pI) 6.31
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:459963 to 460559 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..597 459963..460559 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005972
References cited on this page View Complete Literature Guide for ARL3
1) Huang CF, et al.  (1999) Characterization of a novel ADP-ribosylation factor-like protein (yARL3) in Saccharomyces cerevisiae. J Biol Chem 274(6):3819-27
2) Behnia R, et al.  (2004) Targeting of the Arf-like GTPase Arl3p to the Golgi requires N-terminal acetylation and the membrane protein Sys1p. Nat Cell Biol 6(5):405-13
3) Setty SR, et al.  (2004) Golgi targeting of ARF-like GTPase Arl3p requires its Nalpha-acetylation and the integral membrane protein Sys1p. Nat Cell Biol 6(5):414-9