ARL1/YBR164C Summary Help

Standard Name ARL1 1
Systematic Name YBR164C
Alias DLP2 2
Feature Type ORF, Verified
Description Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; role in membrane organization at trans-Golgi network; G protein of the Ras superfamily, similar to ADP-ribosylation factor (1, 3, 4, 5)
Name Description ADP-Ribosylation factor-Like 1
Chromosomal Location
ChrII:568426 to 567875 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All ARL1 GO evidence and references
  View Computational GO annotations for ARL1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 3 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
Resources
579 total interaction(s) for 265 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Affinity Capture-RNA: 3
  • Affinity Capture-Western: 9
  • Biochemical Activity: 3
  • Co-localization: 3
  • Co-purification: 1
  • PCA: 1
  • Reconstituted Complex: 4
  • Two-hybrid: 6

Genetic Interactions
  • Dosage Rescue: 16
  • Negative Genetic: 328
  • Phenotypic Enhancement: 68
  • Phenotypic Suppression: 16
  • Positive Genetic: 41
  • Synthetic Growth Defect: 42
  • Synthetic Lethality: 32
  • Synthetic Rescue: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 183
Molecular Weight (Da) 20,434
Isoelectric Point (pI) 4.64
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrII:568426 to 567875 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..552 568426..567875 2011-02-03 1997-01-28
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000368
References cited on this page View Complete Literature Guide for ARL1
1) Lee FJ, et al.  (1997) Characterization of an ADP-ribosylation factor-like 1 protein in Saccharomyces cerevisiae. J Biol Chem 272(49):30998-1005
2) Abudugupur A, et al.  (2002) An ARL1 mutation affected autophagic cell death in yeast, causing a defect in central vacuole formation. Cell Death Differ 9(2):158-68
3) Rosenwald AG, et al.  (2002) ARL1 and membrane traffic in Saccharomyces cerevisiae. Yeast 19(12):1039-56
4) Munson AM, et al.  (2004) Yeast ARL1 encodes a regulator of K+ influx. J Cell Sci 117(Pt 11):2309-20
5) Tsai PC, et al.  (2013) Arl1p regulates spatial membrane organization at the trans-Golgi network through interaction with Arf-GEF Gea2p and flippase Drs2p. Proc Natl Acad Sci U S A 110(8):E668-77