ARK1/YNL020C Summary Help

Standard Name ARK1 1
Systematic Name YNL020C
Feature Type ORF, Verified
Description Serine/threonine protein kinase; involved in regulation of the cortical actin cytoskeleton; involved in control of endocytosis; ARK1 has a paralog, PRK1, that arose from the whole genome duplication (1, 2, 3)
Name Description Actin Regulating Kinase 1
Chromosomal Location
ChrXIV:597539 to 595623 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All ARK1 GO evidence and references
  View Computational GO annotations for ARK1
Molecular Function
Manually curated
High-throughput
Biological Process
Manually curated
High-throughput
Cellular Component
Manually curated
High-throughput
Regulators 70 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
85 total interaction(s) for 67 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 14
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 1
  • Biochemical Activity: 9
  • PCA: 1
  • Protein-peptide: 3
  • Reconstituted Complex: 4
  • Two-hybrid: 4

Genetic Interactions
  • Dosage Growth Defect: 11
  • Dosage Rescue: 1
  • Negative Genetic: 21
  • Phenotypic Enhancement: 3
  • Positive Genetic: 6
  • Synthetic Growth Defect: 1
  • Synthetic Lethality: 2
  • Synthetic Rescue: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 638
Molecular Weight (Da) 71,372
Isoelectric Point (pI) 9.25
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIV:597539 to 595623 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1917 597539..595623 2011-02-03 1997-01-28
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004965
References cited on this page View Complete Literature Guide for ARK1
1) Cope MJ, et al.  (1999) Novel protein kinases Ark1p and Prk1p associate with and regulate the cortical actin cytoskeleton in budding yeast. J Cell Biol 144(6):1203-18
2) Smythe E and Ayscough KR  (2003) The Ark1/Prk1 family of protein kinases. Regulators of endocytosis and the actin skeleton. EMBO Rep 4(3):246-51
3) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61