ARG4/YHR018C Summary Help

ARG4 BASIC INFORMATION

Standard Name ARG4
Systematic Name YHR018C
Feature Type ORF, Verified
Description Argininosuccinate lyase, catalyzes the final step in the arginine biosynthesis pathway (1 and see Summary Paragraph)
Name Description ARGinine requiring
GO Annotations All ARG4 GO evidence and references
    View Computational GO annotations for ARG4
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Pathways
Mutant Phenotype All ARG4 Phenotype details and references
Classical genetics
reduction of function
Large-scale survey
null
Interactions ARG4 All interactions details and references
8 total interaction(s) for 8 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Affinity Capture-RNA: 1
  • Two-hybrid: 1
Genetic Interactions
  • Synthetic Lethality: 3
Sequence Information
ChrVIII:141395 to 140004 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
This feature contains embedded feature(s): ARS2
Gbrowse
Genetic position: 12 cM
Last Update Coordinates: 2005-11-07 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1392 141395..140004 2005-11-07 1996-07-31
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000001060

ARG4 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
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  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for ARG4

SUMMARY PARAGRAPH for ARG4

ARG4 encodes arginosuccinate lyase (1), a cytosolic enzyme that catalyzes the final step in arginine biosynthesis (2). Transcription of ARG4 is regulated by the general amino acid control mechanism (3, 4, 5); unlike other arginine biosynthetic genes, ARG4 is not regulated specifically in response to arginine (3). The ARG4 gene has been extensively used in studies of meiotic recombination and gene conversion; for reviews see 6 and 7.

Last updated: 1999-10-15

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for ARG4]

1) Beacham IR, et al.  (1984) The nucleotide sequence of the yeast ARG4 gene. Gene 29(3):271-9
2) Jauniaux JC, et al.  (1978) Arginine metabolism in Saccharomyces cerevisiae: subcellular localization of the enzymes. J Bacteriol 133(3):1096-1107
3) Thiry-Blaise LM and Loppes R  (1990) Deletion analysis of the ARG4 promoter of Saccharomyces cerevisiae: a poly(dAdT) stretch involved in gene transcription. Mol Gen Genet 223(3):474-80
4) Messenguy F and Dubois E  (1983) Participation of transcriptional and post-transcriptional regulatory mechanisms in the control of arginine metabolism in yeast. Mol Gen Genet 189(1):148-56
5) Hinnebusch A  (1992) "General and Pathway-specific Regulatory Mechanisms Controlling the Synthesis of Amino Acid Biosynthetic Enzymes in Saccharomyces cerevisiae". Pp. 319-414 in The Molecular and Cellular Biology of the Yeast Saccharomyces: Gene Expression, edited by Jones EW, Pringle JR and Broach JR. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press
6) Strathern JN  (1992) Recent writings on yeast recombination. Curr Opin Genet Dev 2(5):691-7
7) Nicolas A and Petes TD  (1994) Polarity of meiotic gene conversion in fungi: contrasting views. Experientia 50(3):242-52