ARG4/YHR018C Summary Help

Standard Name ARG4
Systematic Name YHR018C
Feature Type ORF, Verified
Description Argininosuccinate lyase; catalyzes the final step in the arginine biosynthesis pathway (1 and see Summary Paragraph)
Name Description ARGinine requiring
Chromosomal Location
ChrVIII:141402 to 140011 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Genetic position: 12 cM
Gene Ontology Annotations All ARG4 GO evidence and references
  View Computational GO annotations for ARG4
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 10 genes
Resources
Pathways
Classical genetics
null
reduction of function
Large-scale survey
null
Resources
14 total interaction(s) for 13 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 4
  • Affinity Capture-RNA: 3
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Lethality: 1
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 463
Molecular Weight (Da) 51,989
Isoelectric Point (pI) 5.55
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVIII:141402 to 140011 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
This feature contains embedded feature(s): ARS2
SGD ORF map
Genetic position: 12 cM
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1392 141402..140011 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001060
SUMMARY PARAGRAPH for ARG4

ARG4 encodes arginosuccinate lyase (1), a cytosolic enzyme that catalyzes the final step in arginine biosynthesis (2). Transcription of ARG4 is regulated by the general amino acid control mechanism (3, 4, 5); unlike other arginine biosynthetic genes, ARG4 is not regulated specifically in response to arginine (3). The ARG4 gene has been extensively used in studies of meiotic recombination and gene conversion; for reviews see 6 and 7.

Last updated: 1999-10-15 Contact SGD

References cited on this page View Complete Literature Guide for ARG4
1) Beacham IR, et al.  (1984) The nucleotide sequence of the yeast ARG4 gene. Gene 29(3):271-9
2) Jauniaux JC, et al.  (1978) Arginine metabolism in Saccharomyces cerevisiae: subcellular localization of the enzymes. J Bacteriol 133(3):1096-1107
3) Thiry-Blaise LM and Loppes R  (1990) Deletion analysis of the ARG4 promoter of Saccharomyces cerevisiae: a poly(dAdT) stretch involved in gene transcription. Mol Gen Genet 223(3):474-80
4) Messenguy F and Dubois E  (1983) Participation of transcriptional and post-transcriptional regulatory mechanisms in the control of arginine metabolism in yeast. Mol Gen Genet 189(1):148-56
5) Hinnebusch A  (1992) "General and Pathway-specific Regulatory Mechanisms Controlling the Synthesis of Amino Acid Biosynthetic Enzymes in Saccharomyces cerevisiae". Pp. 319-414 in The Molecular and Cellular Biology of the Yeast Saccharomyces: Gene Expression, edited by Jones EW, Pringle JR and Broach JR. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press
6) Strathern JN  (1992) Recent writings on yeast recombination. Curr Opin Genet Dev 2(5):691-7
7) Nicolas A and Petes TD  (1994) Polarity of meiotic gene conversion in fungi: contrasting views. Experientia 50(3):242-52