ORT1/YOR130C Summary Help

ORT1 BASIC INFORMATION

Standard Name ORT1
Systematic Name YOR130C
Alias ARG11
Feature Type ORF, Verified
Description Ornithine transporter of the mitochondrial inner membrane, exports ornithine from mitochondria as part of arginine biosynthesis; human ortholog is associated with hyperammonaemia-hyperornithinaemia-homocitrullinuria (HHH) syndrome (1, 2 and see Summary Paragraph)
Name Description ORnithine Transporter
GO Annotations All ORT1 GO evidence and references
    View Computational GO annotations for ORT1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All ORT1 Phenotype details and references
Large-scale survey
null
Interactions ORT1 All interactions details and references
5 total interaction(s) for 5 unique genes/features.
Physical Interactions
  • Two-hybrid: 1
Genetic Interactions
  • Synthetic Growth Defect: 1
  • Synthetic Lethality: 3
Sequence Information
ChrXV:570808 to 569930 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 2006-01-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..879 570808..569930 2006-01-05 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000005656

ORT1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for ORT1

SUMMARY PARAGRAPH for ORT1

ORT1 encodes an ornithine transporter localized to the mitochondrial inner membrane (1, 2). In yeast, ornithine is synthesized in the mitochondrial matrix and transported to the cytosol, where it is converted to arginine (3). Mutations in ORT1 cause slow growth in the absence of arginine (1); the residual growth may be due to Bac1p, another mitochondrial inner membrane transporter (4). Mutations in ORNT1, a human gene orthologous to ORT1, are associated with hyperammonemia-hyperornithinemia-homocitrullinuria (HHH) syndrome (OMIM) (5).

Last updated: 2005-07-01

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for ORT1]

1) Crabeel M, et al.  (1996) The ARG11 gene of Saccharomyces cerevisiae encodes a mitochondrial integral membrane protein required for arginine biosynthesis. J Biol Chem 271(40):25011-8
2) Palmieri L, et al.  (1997) Identification of the yeast ARG-11 gene as a mitochondrial ornithine carrier involved in arginine biosynthesis. FEBS Lett 410(2-3):447-51
3) Jauniaux JC, et al.  (1978) Arginine metabolism in Saccharomyces cerevisiae: subcellular localization of the enzymes. J Bacteriol 133(3):1096-1107
4) Soetens O, et al.  (1998) Transport of arginine and ornithine into isolated mitochondria of Saccharomyces cerevisiae. Eur J Biochem 258(2):702-9
5) Camacho JA, et al.  (1999) Hyperornithinaemia-hyperammonaemia-homocitrullinuria syndrome is caused by mutations in a gene encoding a mitochondrial ornithine transporter. Nat Genet 22(2):151-8