ARF3/YOR094W Summary Help

ARF3 BASIC INFORMATION

Standard Name ARF3 1
Systematic Name YOR094W
Alias ARL2
Feature Type ORF, Verified
Description Glucose-repressible ADP-ribosylation factor, GTPase of the Ras superfamily involved in development of polarity (1, 2 and see Summary Paragraph)
Name Description ADP-Ribosylation Factor 1
GO Annotations All ARF3 GO evidence and references
    View Computational GO annotations for ARF3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All ARF3 Phenotype details and references
Classical genetics
null
Large-scale survey
null
Interactions ARF3 All interactions details and references
29 total interaction(s) for 21 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 3
  • Biochemical Activity: 1
  • Co-localization: 2
  • PCA: 6
  • Reconstituted Complex: 1
  • Two-hybrid: 3
Genetic Interactions
  • Dosage Rescue: 8
  • Phenotypic Enhancement: 3
  • Synthetic Growth Defect: 1
Sequence Information
ChrXV:502796 to 503347 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 2006-01-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..552 502796..503347 2006-01-05 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000005620

ARF3 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
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  • Functional Analysis

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Expression Summary histogram

ADDITIONAL INFORMATION for ARF3

SUMMARY PARAGRAPH for ARF3

ARF3 encodes one of three ADP ribosylation factors (ARFs) identified in S. cerevisiae (1). ARFs are GTPases of the Ras superfamily that regulate the formation of coated vesicles in intracellular trafficking (3, 4). The process of vesicle formation in the exocytic and endocytic pathways has been recently reviewed (5), as has the role of ARF (6). Yeast ARF activity is regulated by the guanine nucleotide exchange factors Sec7p, Gea1p, and Gea2p (7, 8) and by the GTPase activating proteins Gcs1p (9) and Glo3p (10). Arf3p is not essential for viability or for ER to Golgi transport, and cannot substitute for Arf1p and Arf2p (1).

Last updated: 1999-10-28

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for ARF3]

1) Lee FJ, et al.  (1994) Characterization of a glucose-repressible ADP-ribosylation factor 3 (ARF3) from Saccharomyces cerevisiae. J Biol Chem 269(33):20931-7
2) Huang CF, et al.  (2003) Role for Arf3p in development of polarity, but not endocytosis, in Saccharomyces cerevisiae. Mol Biol Cell 14(9):3834-47
3) Moss J and Vaughan M  (1998) Molecules in the ARF orbit. J Biol Chem 273(34):21431-4
4) Moss J and Vaughan M  (1999) Activation of toxin ADP-ribosyltransferases by eukaryotic ADP-ribosylation factors. Mol Cell Biochem 193(1-2):153-7
5) Springer S, et al.  (1999) A primer on vesicle budding. Cell 97(2):145-8
6) Roth MG  (1999) Snapshots of ARF1: implications for mechanisms of activation and inactivation. Cell 97(2):149-52
7) Peyroche A, et al.  (1996) Nucleotide exchange on ARF mediated by yeast Gea1 protein. Nature 384(6608):479-81
8) Sata M, et al.  (1998) Brefeldin A-inhibited guanine nucleotide-exchange activity of Sec7 domain from yeast Sec7 with yeast and mammalian ADP ribosylation factors. Proc Natl Acad Sci U S A 95(8):4204-8
9) Poon PP, et al.  (1996) Saccharomyces cerevisiae Gcs1 is an ADP-ribosylation factor GTPase-activating protein. Proc Natl Acad Sci U S A 93(19):10074-7
10) Poon PP, et al.  (1999) Retrograde transport from the yeast Golgi is mediated by two ARF GAP proteins with overlapping function. EMBO J 18(3):555-64