ARE2/YNR019W Summary

ARE2 BASIC INFORMATION

Standard Name	ARE2 1
Systematic Name	YNR019W
Alias	SAT1 2
Feature Type	ORF, Verified
Description	Acyl-CoA:sterol acyltransferase, isozyme of Are1p; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the presence of oxygen (2, 3, 4)
Name Description	Acyl-coenzyme A: cholesterol acyl transferase-Related Enzyme 1

GO Annotations	All ARE2 GO evidence and references
	View Computational GO annotations for ARE2
Molecular Function
Manually curated	ergosterol O-acyltransferase activity (IGI, IMP)
Biological Process
Manually curated	ergosterol metabolic process (IGI, IMP)
Cellular Component
Manually curated	endoplasmic reticulum (IDA)

Mutant Phenotype	All ARE2 Phenotype details and references
Classical genetics
null	beta-1,6-glucan excretion: increased Hsp150p distribution: abnormal resistance to caffeine: decreased sporulation efficiency: decreased
Large-scale survey
null	competitive fitness: decreased resistance to nickel(2+): increased viable
overexpression	vegetative growth: decreased

Interactions	ARE2 All interactions details and references
	36 total interaction(s) for 25 unique genes/features.
Physical Interactions	Affinity Capture-MS: 1 Affinity Capture-RNA: 1 Biochemical Activity: 9 Two-hybrid: 4
Genetic Interactions	Phenotypic Enhancement: 12 Phenotypic Suppression: 8 Synthetic Lethality: 1

Sequence Information

ChrXIV:665342 to 667270 | |

Last Update

Coordinates: 2010-01-05 | Sequence: 1997-01-28

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1929	665342..667270	2010-01-05	1997-01-28

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000005302

ARE2 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for ARE2

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for ARE2]

1)	Yang H, et al. (1996) Sterol esterification in yeast: a two-gene process. Science 272(5266):1353-6
2)	Yu C, et al. (1996) Molecular cloning and characterization of two isoforms of Saccharomyces cerevisiae acyl-CoA:sterol acyltransferase. J Biol Chem 271(39):24157-63
3)	Zweytick D, et al. (2000) Contribution of Are1p and Are2p to steryl ester synthesis in the yeast Saccharomyces cerevisiae. Eur J Biochem 267(4):1075-82
4)	Valachovic M, et al. (2001) Anaerobiosis induces complex changes in sterol esterification pattern in the yeast Saccharomyces cerevisiae. FEMS Microbiol Lett 197(1):41-5

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