ARE2/YNR019W Summary Help

Standard Name ARE2 1
Systematic Name YNR019W
Alias SAT1 2
Feature Type ORF, Verified
Description Acyl-CoA:sterol acyltransferase; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the presence of oxygen; ARE2 has a paralog, ARE1, that arose from the whole genome duplication (2, 3, 4, 5)
Name Description Acyl-coenzyme A: cholesterol acyl transferase-Related Enzyme 1
Chromosomal Location
ChrXIV:665339 to 667267 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All ARE2 GO evidence and references
  View Computational GO annotations for ARE2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 5 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
130 total interaction(s) for 78 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2
  • Affinity Capture-RNA: 1
  • Biochemical Activity: 9
  • PCA: 3
  • Two-hybrid: 1

Genetic Interactions
  • Negative Genetic: 64
  • Phenotypic Enhancement: 20
  • Positive Genetic: 18
  • Synthetic Growth Defect: 4
  • Synthetic Lethality: 8

Resources
Expression Summary
histogram
Resources
Length (a.a.) 642
Molecular Weight (Da) 74,022
Isoelectric Point (pI) 7.71
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIV:665339 to 667267 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1929 665339..667267 2011-02-03 1997-01-28
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005302
References cited on this page View Complete Literature Guide for ARE2
1) Yang H, et al.  (1996) Sterol esterification in yeast: a two-gene process. Science 272(5266):1353-6
2) Yu C, et al.  (1996) Molecular cloning and characterization of two isoforms of Saccharomyces cerevisiae acyl-CoA:sterol acyltransferase. J Biol Chem 271(39):24157-63
3) Zweytick D, et al.  (2000) Contribution of Are1p and Are2p to steryl ester synthesis in the yeast Saccharomyces cerevisiae. Eur J Biochem 267(4):1075-82
4) Valachovic M, et al.  (2001) Anaerobiosis induces complex changes in sterol esterification pattern in the yeast Saccharomyces cerevisiae. FEMS Microbiol Lett 197(1):41-5
5) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61