ARC18/YLR370C Summary Help

Standard Name ARC18 1
Systematic Name YLR370C
Feature Type ORF, Verified
Description Subunit of the ARP2/3 complex; ARP2/3 is required for the motility and integrity of cortical actin patches (1, 2)
Name Description ARp2/3 Complex subunit 1
Chromosomal Location
ChrXII:862254 to 861718 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All ARC18 GO evidence and references
  View Computational GO annotations for ARC18
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 6 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
284 total interaction(s) for 182 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 44
  • Affinity Capture-RNA: 4
  • Affinity Capture-Western: 7
  • Co-localization: 1
  • Co-purification: 6
  • FRET: 1
  • PCA: 11
  • Reconstituted Complex: 1

Genetic Interactions
  • Negative Genetic: 103
  • Phenotypic Enhancement: 2
  • Phenotypic Suppression: 38
  • Positive Genetic: 13
  • Synthetic Growth Defect: 23
  • Synthetic Haploinsufficiency: 1
  • Synthetic Lethality: 29

Resources
Expression Summary
histogram
Resources
Length (a.a.) 178
Molecular Weight (Da) 20,578
Isoelectric Point (pI) 8.11
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXII:862254 to 861718 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..537 862254..861718 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004362
References cited on this page View Complete Literature Guide for ARC18
1) Winter D, et al.  (1997) The complex containing actin-related proteins Arp2 and Arp3 is required for the motility and integrity of yeast actin patches. Curr Biol 7(7):519-29
2) Winter DC, et al.  (1999) Genetic dissection of the budding yeast Arp2/3 complex: a comparison of the in vivo and structural roles of individual subunits. Proc Natl Acad Sci U S A 96(13):7288-93