ARC1/YGL105W Summary Help

Standard Name ARC1
Systematic Name YGL105W
Feature Type ORF, Verified
Description Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases; involved in tRNA delivery, stimulating catalysis, and ensuring localization; also binds quadruplex nucleic acids; protein abundance increases in response to DNA replication stress; methionyl-tRNA synthetase is Mes1p; glutamyl-tRNA synthetase is Gus1p (1, 2, 3, 4, 5, 6)
Name Description Acyl-RNA-Complex
Chromosomal Location
ChrVII:307437 to 308567 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All ARC1 GO evidence and references
  View Computational GO annotations for ARC1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 6 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
unspecified
Resources
220 total interaction(s) for 183 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 47
  • Affinity Capture-RNA: 3
  • Affinity Capture-Western: 4
  • Biochemical Activity: 21
  • Co-crystal Structure: 2
  • PCA: 5
  • Reconstituted Complex: 8

Genetic Interactions
  • Dosage Rescue: 4
  • Negative Genetic: 69
  • Positive Genetic: 51
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 4

Resources
Expression Summary
histogram
Resources
Length (a.a.) 376
Molecular Weight (Da) 42,084
Isoelectric Point (pI) 8.01
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:307437 to 308567 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1131 307437..308567 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003073
References cited on this page View Complete Literature Guide for ARC1
1) Frantz JD and Gilbert W  (1995) A novel yeast gene product, G4p1, with a specific affinity for quadruplex nucleic acids. J Biol Chem 270(35):20692-7
2) Simos G, et al.  (1996) The yeast protein Arc1p binds to tRNA and functions as a cofactor for the methionyl- and glutamyl-tRNA synthetases. EMBO J 15(19):5437-48
3) Simos G, et al.  (1998) A conserved domain within Arc1p delivers tRNA to aminoacyl-tRNA synthetases. Mol Cell 1(2):235-42
4) Galani K, et al.  (2001) The intracellular location of two aminoacyl-tRNA synthetases depends on complex formation with Arc1p. EMBO J 20(23):6889-98
5) Deinert K, et al.  (2001) Arc1p organizes the yeast aminoacyl-tRNA synthetase complex and stabilizes its interaction with the cognate tRNAs. J Biol Chem 276(8):6000-8
6) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76