APT2/YDR441C Summary Help

Standard Name APT2 1
Systematic Name YDR441C
Feature Type ORF, Verified
Description Potential adenine phosphoribosyltransferase; encodes a protein with similarity to adenine phosphoribosyltransferase, but artificially expressed protein exhibits no enzymatic activity; APT2 has a paralog, APT1, that arose from the whole genome duplication (2, 3 and see Summary Paragraph)
Name Description Adenine PhosphoribosylTransferase 1
Chromosomal Location
ChrIV:1345062 to 1344517 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All APT2 GO evidence and references
  View Computational GO annotations for APT2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 10 genes
Resources
Large-scale survey
null
Resources
28 total interaction(s) for 26 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 3
  • Protein-RNA: 1
  • Two-hybrid: 1

Genetic Interactions
  • Negative Genetic: 15
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 5
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 181
Molecular Weight (Da) 19,986
Isoelectric Point (pI) 4.68
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:1345062 to 1344517 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..546 1345062..1344517 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002849
SUMMARY PARAGRAPH for APT2

APT2 is a gene with similarity to adenine phosphoribosyltransferase (APRT) (1). It is likely a pseudogene that arose via duplication of the APRT-encoding gene APT1 (). APT2 expressed in E. coli shows no APRT activity, and the gene is not expressed under normal physiological conditions in yeast (2).

Last updated: 1999-12-31 Contact SGD

References cited on this page View Complete Literature Guide for APT2
1) Yuryev A and Corden JL  (1994) A Saccharomyces cerevisiae gene encoding a potential adenine phosphoribosyltransferase. Yeast 10(5):659-62
2) Alfonzo JD, et al.  (1999) APT1, but not APT2, codes for a functional adenine phosphoribosyltransferase in Saccharomyces cerevisiae. J Bacteriol 181(1):347-52
3) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61