Standard Name	APQ12 1
Systematic Name	YIL040W
Feature Type	ORF, Verified
Description	Protein required for nuclear envelope morphology, nuclear pore complex localization, mRNA export from the nucleus; exhibits synthetic lethal genetic interactions with genes involved in lipid metabolism (1, 2, 3)
Name Description	APical growth revealed by Quantitative morphological analysis

Chromosomal Location	ChrIX:277723 to 278139 | ORF Map | GBrowse

	View Computational GO annotations for APQ12
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	cellular lipid metabolic process (IGI) mRNA export from nucleus (IMP) nuclear envelope organization (IMP)
Cellular Component
Manually curated	nuclear envelope (IDA)
High-throughput	endoplasmic reticulum (IDA)

Classical genetics
null	cell cycle progression: abnormal cold sensitivity: increased nuclear export: decreased Nup82p-GFP distribution: abnormal resistance to cerulenin: decreased resistance to oleic acid: decreased vegetative growth: decreased rate
Large-scale survey
null	acid pH resistance: decreased bud morphology: abnormal cell size: increased competitive fitness: decreased fermentative growth: decreased rate filamentous growth: decreased invasive growth: absent metal resistance: decreased resistance to cycloheximide: decreased resistance to spermine: decreased resistance to hygromycin B: decreased resistance to 1,4-dithiothreitol: decreased resistance to tunicamycin: decreased resistance to propolis extract: decreased resistance to hydroxyurea: decreased resistance to wortmannin: decreased resistance to sirolimus: decreased resistance to tunicamycin: increased resistance to mycophenolic acid: increased resistance to fluconazole: increased resistance to bleomycin: increased resistance to caffeine: decreased resistance to fenpropimorph: decreased resistance to methyl methanesulfonate: decreased resistance to sodium selenide: decreased resistance to mefloquine: decreased thermotolerance: decreased transposable element transposition: decreased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	610 total interaction(s) for 412 unique genes/features.
Physical Interactions	Affinity Capture-MS: 1
Genetic Interactions	Dosage Rescue: 2 Negative Genetic: 390 Phenotypic Suppression: 1 Positive Genetic: 151 Synthetic Growth Defect: 37 Synthetic Lethality: 19 Synthetic Rescue: 9
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIX:277723 to 278139 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1994-12-10
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..417 277723..278139 2011-02-03 1994-12-10
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB382 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001302