APL5/YPL195W Summary Help

Standard Name APL5 1
Systematic Name YPL195W
Alias YKS4 2
Feature Type ORF, Verified
Description Delta adaptin-like subunit of the clathrin associated protein complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; suppressor of loss of casein kinase 1 function; the clathrin associated protein complex is also known as AP-3 (1, 2, 3)
Name Description clathrin Adaptor Protein complex Large chain 1
Chromosomal Location
ChrXVI:176223 to 179021 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All APL5 GO evidence and references
  View Computational GO annotations for APL5
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 2 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
216 total interaction(s) for 109 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 23
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 5
  • Co-fractionation: 1
  • Co-purification: 2
  • PCA: 1
  • Reconstituted Complex: 11
  • Two-hybrid: 3

Genetic Interactions
  • Negative Genetic: 141
  • Positive Genetic: 16
  • Synthetic Growth Defect: 6
  • Synthetic Lethality: 3
  • Synthetic Rescue: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 932
Molecular Weight (Da) 106,923
Isoelectric Point (pI) 4.8
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:176223 to 179021 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2799 176223..179021 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000006116
References cited on this page View Complete Literature Guide for APL5
1) Cowles CR, et al.  (1997) The AP-3 adaptor complex is essential for cargo-selective transport to the yeast vacuole. Cell 91(1):109-18
2) Panek HR, et al.  (1997) Suppressors of YCK-encoded yeast casein kinase 1 deficiency define the four subunits of a novel clathrin AP-like complex. EMBO J 16(14):4194-204
3) Rehling P, et al.  (1999) Formation of AP-3 transport intermediates requires Vps41 function. Nat Cell Biol 1(6):346-53