APL4/YPR029C Summary Help

Standard Name APL4
Systematic Name YPR029C
Feature Type ORF, Verified
Description Gamma-adaptin; large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport (1, 2)
Name Description clathrin Adaptor Protein complex Large chain
Chromosomal Location
ChrXVI:626967 to 624469 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All APL4 GO evidence and references
  View Computational GO annotations for APL4
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 5 genes
Resources
Classical genetics
null
reduction of function
Large-scale survey
null
overexpression
Resources
148 total interaction(s) for 95 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 39
  • Affinity Capture-Western: 6
  • Biochemical Activity: 1
  • Co-purification: 1
  • PCA: 10
  • Reconstituted Complex: 2
  • Two-hybrid: 6

Genetic Interactions
  • Dosage Growth Defect: 1
  • Negative Genetic: 58
  • Phenotypic Enhancement: 1
  • Positive Genetic: 15
  • Synthetic Growth Defect: 4
  • Synthetic Lethality: 2
  • Synthetic Rescue: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 832
Molecular Weight (Da) 93,623
Isoelectric Point (pI) 5.17
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:626967 to 624469 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2499 626967..624469 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000006233
References cited on this page View Complete Literature Guide for APL4
1) Panek HR, et al.  (1997) Suppressors of YCK-encoded yeast casein kinase 1 deficiency define the four subunits of a novel clathrin AP-like complex. EMBO J 16(14):4194-204
2) Kirchhausen T  (2000) Three ways to make a vesicle. Nat Rev Mol Cell Biol 1(3):187-98