Standard Name	APC5 1
Systematic Name	YOR249C
Alias	RMC1 2
Feature Type	ORF, Verified
Description	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; relative distribution to nuclear foci decreases upon DNA replication stress (1, 3, 4, 5)
Name Description	Anaphase Promoting Complex 1

Chromosomal Location	ChrXV:800731 to 798674 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for APC5
Molecular Function
Manually curated	contributes_to ubiquitin-protein ligase activity (IDA)
Biological Process
Manually curated	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (IMP) chromatin assembly (IMP) protein ubiquitination (IMP)
Cellular Component
Manually curated	anaphase-promoting complex (IDA)
High-throughput	nucleus (IDA)

Classical genetics
reduction of function	cell cycle progression through the G2/M phase transition: arrested chronological lifespan: decreased heat sensitivity: increased replicative lifespan: decreased resistance to benomyl: increased
Large-scale survey
null	haploinsufficient inviable
reduction of function	competitive fitness: increased
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	230 total interaction(s) for 152 unique genes/features.
Physical Interactions	Affinity Capture-MS: 54 Affinity Capture-RNA: 1 Affinity Capture-Western: 7 Biochemical Activity: 4 Co-crystal Structure: 1 Reconstituted Complex: 1 Two-hybrid: 3
Genetic Interactions	Dosage Growth Defect: 4 Dosage Rescue: 11 Negative Genetic: 81 Phenotypic Enhancement: 7 Phenotypic Suppression: 5 Positive Genetic: 14 Synthetic Growth Defect: 13 Synthetic Lethality: 8 Synthetic Rescue: 16
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:800731 to 798674 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2058 800731..798674 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005775