APC11/YDL008W Summary Help

Standard Name APC11 1
Systematic Name YDL008W
Feature Type ORF, Verified
Description Catalytic core subunit, Anaphase-Promoting Complex/Cyclosome (APC/C); which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; contains a RING-H2 domain that is required for activity (1, 2)
Name Description Anaphase Promoting Complex 1
Chromosomal Location
ChrIV:433497 to 433994 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All APC11 GO evidence and references
  View Computational GO annotations for APC11
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 2 genes
Resources
Classical genetics
conditional
null
Large-scale survey
conditional
null
reduction of function
unspecified
Resources
78 total interaction(s) for 47 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 27
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 7
  • Biochemical Activity: 6
  • Co-crystal Structure: 1
  • PCA: 2
  • Reconstituted Complex: 7
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Growth Defect: 1
  • Dosage Rescue: 3
  • Negative Genetic: 5
  • Synthetic Growth Defect: 8
  • Synthetic Lethality: 8

Resources
Expression Summary
histogram
Resources
Length (a.a.) 165
Molecular Weight (Da) 18,865
Isoelectric Point (pI) 4.58
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:433497 to 433994 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..498 433497..433994 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002166
References cited on this page View Complete Literature Guide for APC11
1) Zachariae W, et al.  (1998) Mass spectrometric analysis of the anaphase-promoting complex from yeast: identification of a subunit related to cullins. Science 279(5354):1216-9
2) Zachariae W and Nasmyth K  (1999) Whose end is destruction: cell division and the anaphase-promoting complex. Genes Dev 13(16):2039-58