APC11/YDL008W Summary Help

Standard Name APC11 1
Systematic Name YDL008W
Feature Type ORF, Verified
Description Catalytic core subunit, Anaphase-Promoting Complex/Cyclosome (APC/C); which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; contains a RING-H2 domain that is required for activity (1, 2)
Name Description Anaphase Promoting Complex 1
Chromosomal Location
ChrIV:433497 to 433994 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All APC11 GO evidence and references
  View Computational GO annotations for APC11
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 66 genes
Resources
Classical genetics
conditional
null
Large-scale survey
conditional
null
reduction of function
unspecified
Resources
75 total interaction(s) for 45 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 27
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 7
  • Biochemical Activity: 5
  • Co-crystal Structure: 1
  • PCA: 2
  • Reconstituted Complex: 6
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Growth Defect: 1
  • Dosage Rescue: 3
  • Negative Genetic: 5
  • Synthetic Growth Defect: 8
  • Synthetic Lethality: 8

Resources
Expression Summary
histogram
Resources
Length (a.a.) 165
Molecular Weight (Da) 18,865
Isoelectric Point (pI) 4.58
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:433497 to 433994 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..498 433497..433994 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002166
References cited on this page View Complete Literature Guide for APC11
1) Zachariae W, et al.  (1998) Mass spectrometric analysis of the anaphase-promoting complex from yeast: identification of a subunit related to cullins. Science 279(5354):1216-9
2) Zachariae W and Nasmyth K  (1999) Whose end is destruction: cell division and the anaphase-promoting complex. Genes Dev 13(16):2039-58