APC11/YDL008W Summary

APC11 BASIC INFORMATION

Standard Name	APC11
Systematic Name	YDL008W
Feature Type	ORF, Verified
Description	Catalytic core subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition (1, 2)
Name Description	Anaphase Promoting Complex subunit

GO Annotations	All APC11 GO evidence and references
	View Computational GO annotations for APC11
Molecular Function
Manually curated	protein binding (TAS) ubiquitin-protein ligase activity (IDA, TAS)
Biological Process
Manually curated	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (IPI) cyclin catabolic process (TAS) mitotic metaphase/anaphase transition (TAS) mitotic sister chromatid segregation (TAS) mitotic spindle elongation (TAS) protein ubiquitination (IPI)
Cellular Component
Manually curated	anaphase-promoting complex (IDA)

Mutant Phenotype	All APC11 Phenotype details and references
Large-scale survey
null	inviable

Interactions	APC11 All interactions details and references
	48 total interaction(s) for 31 unique genes/features.
Physical Interactions	Affinity Capture-MS: 25 Affinity Capture-Western: 3 Biochemical Activity: 1 PCA: 2 Two-hybrid: 1
Genetic Interactions	Dosage Growth Defect: 1 Synthetic Growth Defect: 4 Synthetic Lethality: 11

Sequence Information

ChrIV:433495 to 433992 | |

Last Update

Coordinates: 2008-06-05 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..498	433495..433992	2008-06-05	1996-07-31

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000002166

APC11 RESOURCES

Click on map for expanded view

SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for APC11

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for APC11]

1)	Zachariae W, et al. (1998) Mass spectrometric analysis of the anaphase-promoting complex from yeast: identification of a subunit related to cullins. Science 279(5354):1216-9
2)	Zachariae W and Nasmyth K (1999) Whose end is destruction: cell division and the anaphase-promoting complex. Genes Dev 13(16):2039-58

SGD^tm pages Database Copyright © 1997-2010 The Board of Trustees of Leland Stanford Junior University. Permission to use the information contained in this database was given by the researchers/institutes who contributed or published the information. Users of the database are solely responsible for compliance with any copyright restrictions, including those applying to the author abstracts. Documents from this server are provided "AS-IS" without any warranty, expressed or implied. The SGD project at Stanford University is supported by a Genome Research Resource Grant from the US National Human Genome Research Institute, part of the US National Institutes of Health.