Standard Name	AMN1 1
Systematic Name	YBR158W
Alias	ICS4 2 , CST13 3
Feature Type	ORF, Verified
Description	Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN) (1, 3)
Name Description	Antagonist of Mitotic exit Network 1

Chromosomal Location	ChrII:556549 to 558198 | ORF Map | GBrowse

	View Computational GO annotations for AMN1
Molecular Function
Manually curated	protein binding (IPI)
Biological Process
Manually curated	mitotic cell cycle checkpoint (IMP) negative regulation of exit from mitosis (IGI, IMP)
Cellular Component
Manually curated	cellular bud (IDA) cytoplasm (IDA) nucleus (IDA)

Classical genetics
null	vegetative growth: decreased viable
overexpression	cell cycle progression in G2 phase: abnormal cellular morphology: abnormal colony sectoring: increased mitotic recombination: increased nuclear morphology: abnormal
Large-scale survey
null	competitive fitness: decreased filamentous growth: decreased invasive growth: absent vacuolar morphology: abnormal viable
overexpression	colony sectoring: increased inviable vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	51 total interaction(s) for 39 unique genes/features.
Physical Interactions	Affinity Capture-MS: 6 Affinity Capture-RNA: 1 Affinity Capture-Western: 3 Reconstituted Complex: 1 Two-hybrid: 1
Genetic Interactions	Dosage Lethality: 16 Dosage Rescue: 1 Negative Genetic: 13 Phenotypic Suppression: 2 Synthetic Lethality: 1 Synthetic Rescue: 6
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrII:556549 to 558198 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1650 556549..558198 2011-02-03 1997-01-28
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000362