Standard Name	AMD1
Systematic Name	YML035C
Alias	AMD3
Feature Type	ORF, Verified
Description	AMP deaminase; tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia; thought to be involved in regulation of intracellular purine (adenine, guanine, and inosine) nucleotide pools (1, 2, 3, 4, 5, 6)
Name Description	AMP Deaminase

Chromosomal Location	ChrXIII:208860 to 206428 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for AMD1
Molecular Function
Manually curated	AMP deaminase activity (IDA, IMP)
Biological Process
Manually curated	guanine salvage (IGI, IMP) purine nucleotide metabolic process (IGI, IMP)
Cellular Component
High-throughput	cytoplasm (IDA)

Pathways	salvage pathways of adenine, hypoxanthine, and their nucleosides salvage pathways of purines and their nucleosides superpathway of purine biosynthesis and salvage pathways

Classical genetics
null	budding: decreased rate resistance to adenine: decreased toxin resistance: increased
reduction of function	viable
Large-scale survey
null	competitive fitness: increased heat sensitivity: increased resistance to hydroxyurea: decreased resistance to acetaldehyde: decreased resistance to benzo[a]pyrene: increased stress resistance: increased vacuolar morphology: abnormal vegetative growth: decreased rate viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	92 total interaction(s) for 84 unique genes/features.
Physical Interactions	Affinity Capture-MS: 6 Biochemical Activity: 11 PCA: 2 Protein-peptide: 5 Protein-RNA: 1 Reconstituted Complex: 1 Two-hybrid: 6
Genetic Interactions	Negative Genetic: 43 Phenotypic Enhancement: 2 Positive Genetic: 14 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIII:208860 to 206428 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2433 208860..206428 1996-07-31 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004498