AMD1/YML035C Summary

AMD1 BASIC INFORMATION

Standard Name	AMD1
Systematic Name	YML035C
Alias	AMD3
Feature Type	ORF, Verified
Description	AMP deaminase, tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia; may be involved in regulation of intracellular adenine nucleotide pools (1, 2)
Name Description	AMP Deaminase

GO Annotations	All AMD1 GO evidence and references
	View Computational GO annotations for AMD1
Molecular Function
Manually curated	AMP deaminase activity (IDA)
Biological Process
Manually curated	purine nucleotide metabolic process (IC)
Cellular Component
High-throughput	cytoplasm (IDA)

Pathways	salvage pathways of adenine, hypoxanthine, and their nucleosides salvage pathways of purines and their nucleosides superpathway of purine biosynthesis and salvage pathways

Mutant Phenotype	All AMD1 Phenotype details and references
Classical genetics
null	toxin resistance: increased
Large-scale survey
null	resistance to hydroxyurea: decreased resistance to acetaldehyde: decreased viable

Interactions	AMD1 All interactions details and references
	24 total interaction(s) for 20 unique genes/features.
Physical Interactions	Affinity Capture-MS: 4 Biochemical Activity: 11 PCA: 1 Protein-RNA: 1 Two-hybrid: 6
Genetic Interactions	Synthetic Growth Defect: 1

Sequence Information

ChrXIII:208860 to 206428 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..2433	208860..206428	1996-07-31	1996-07-31

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000004498

AMD1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for AMD1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for AMD1]

1)	Merkler DJ and Schramm VL (1990) Catalytic and regulatory site composition of yeast AMP deaminase by comparative binding and rate studies. Resolution of the cooperative mechanism. J Biol Chem 265(8):4420-6
2)	Merkler DJ, et al. (1989) AMP deaminase from yeast. Role in AMP degradation, large scale purification, and properties of the native and proteolyzed enzyme. J Biol Chem 264(35):21422-30

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