Standard Name	ALY2 1, 2
Systematic Name	YJL084C
Alias	ART3 3
Feature Type	ORF, Verified
Description	Alpha arrestin that controls nutrient-mediated intracellular sorting of permease Gap1p; interacts with AP-1 subunit Apl4p; phosphorylated by Npr1p and also by cyclin-CDK complex Pcl7p-Pho85p; promotes endocytosis of plasma membrane proteins; ALY2 has a paralog, ALY1, that arose from the whole genome duplication (4, 5, 6, 7)
Name Description	Arrestin-Like Yeast protein 1

Chromosomal Location	ChrX:278002 to 274862 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for ALY2
Molecular Function
Manually curated	protein binding, bridging (IPI) ubiquitin protein ligase binding (IPI)
Biological Process
Manually curated	positive regulation of ubiquitin-dependent endocytosis (IMP) regulation of intracellular transport (IMP) ubiquitin-dependent endocytosis (ISA)
Cellular Component
Manually curated	early endosome (IDA) late endosome (IDA)
High-throughput	cytoplasm (IDA)

Classical genetics
null	Dip5p modification: decreased resistance to (S)-azetidine-2-carboxylic acid: increased resistance to L-canavanine: increased resistance to sirolimus: decreased
overexpression	resistance to L-canavanine: decreased resistance to (S)-azetidine-2-carboxylic acid: decreased resistance to sirolimus: increased
Large-scale survey
null	competitive fitness: increased Fus-Mid-GFP distribution: abnormal resistance to cycloheximide: decreased resistance to streptomycin: decreased sporulation: normal vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	76 total interaction(s) for 59 unique genes/features.
Physical Interactions	Affinity Capture-MS: 14 Affinity Capture-RNA: 1 Affinity Capture-Western: 11 Biochemical Activity: 22 Protein-peptide: 1 Reconstituted Complex: 2 Two-hybrid: 4
Genetic Interactions	Dosage Rescue: 1 Negative Genetic: 14 Phenotypic Enhancement: 1 Synthetic Growth Defect: 1 Synthetic Rescue: 4
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrX:278002 to 274862 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1997-07-27
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..3141 278002..274862 2011-02-03 1997-07-27
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003620