Standard Name	ALY1 1, 2
Systematic Name	YKR021W
Alias	ART6 3
Feature Type	ORF, Verified
Description	Alpha arrestin that controls nutrient-mediated intracellular sorting of permease Gap1p; interacts with AP-1 subunit Apl4p; may regulate endocytosis of plasma membrane proteins by recruiting ubiquitin ligase Rsp5p to plasma membrane targets; ALY1 has a paralog, ALY2, that arose from the whole genome duplication (3, 4, 5, 6)
Name Description	Arrestin-Like Yeast protein 1

Chromosomal Location	ChrXI:479234 to 481981 | ORF Map | GBrowse

	View Computational GO annotations for ALY1
Molecular Function
Manually curated	ubiquitin protein ligase binding (IPI)
Biological Process
Manually curated	positive regulation of ubiquitin-dependent endocytosis (IGI) regulation of intracellular transport (IMP) ubiquitin-dependent endocytosis (ISA)
Cellular Component
Manually curated	early endosome (IDA) late endosome (IDA)
High-throughput	cytoplasm (IDA)

Classical genetics
null	resistance to sirolimus: decreased resistance to L-canavanine: increased resistance to (S)-azetidine-2-carboxylic acid: increased viable
overexpression	resistance to sirolimus: increased resistance to (S)-azetidine-2-carboxylic acid: decreased resistance to L-canavanine: decreased
Large-scale survey
null	competitive fitness: decreased haploproficient resistance to methyl methanesulfonate: decreased respiratory growth: decreased rate vacuolar morphology: abnormal viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	30 total interaction(s) for 22 unique genes/features.
Physical Interactions	Affinity Capture-MS: 8 Affinity Capture-RNA: 1 Affinity Capture-Western: 5 Biochemical Activity: 5 Protein-RNA: 1 Reconstituted Complex: 2 Two-hybrid: 1
Genetic Interactions	Dosage Growth Defect: 1 Dosage Lethality: 1 Dosage Rescue: 1 Negative Genetic: 1 Phenotypic Enhancement: 1 Synthetic Growth Defect: 1 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXI:479234 to 481981 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 2011-02-03
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2748 479234..481981 2011-02-03 2011-02-03
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001729