Standard Name	ALR1 1 (see Nomenclature conflict Note)
Systematic Name	YOL130W
Alias	SWC3 2
Feature Type	ORF, Verified
Description	Plasma membrane Mg(2+) transporter, expression and turnover are regulated by Mg(2+) concentration; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions (1, 3, 4)
Name Description	ALuminum Resistance 1

Chromosomal Location	ChrXV:74400 to 76979 | ORF Map | GBrowse

	View Computational GO annotations for ALR1
Molecular Function
Manually curated	inorganic cation transmembrane transporter activity (IMP)
Biological Process
Manually curated	cation transport (IMP) magnesium ion transport (IDA)
Cellular Component
Manually curated	plasma membrane (IDA, IMP)
High-throughput	integral to membrane (ISM)

Classical genetics
null	magnesium accumulation: decreased growth in exponential phase: decreased rate vegetative growth: decreased rate
Large-scale survey
null	inviable
overexpression	resistance to sirolimus: decreased vegetative growth: decreased
reduction of function	competitive fitness: decreased resistance to benomyl: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	43 total interaction(s) for 37 unique genes/features.
Physical Interactions	Affinity Capture-MS: 3 Affinity Capture-RNA: 1 Biochemical Activity: 6 PCA: 3 Two-hybrid: 5
Genetic Interactions	Dosage Lethality: 1 Dosage Rescue: 1 Negative Genetic: 14 Phenotypic Enhancement: 2 Phenotypic Suppression: 1 Synthetic Growth Defect: 1 Synthetic Lethality: 1 Synthetic Rescue: 4
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:74400 to 76979 | ORF Map | GBrowse
Last Update	Coordinates: 2006-01-05 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2580 74400..76979 2006-01-05 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | TCDB | UniProtKB

Primary SGDID	S000005490