AKR1/YDR264C Summary Help

Standard Name AKR1
Systematic Name YDR264C
Feature Type ORF, Verified
Description Palmitoyl transferase involved in protein palmitoylation; acts as a negative regulator of pheromone response pathway; required for endocytosis of pheromone receptors; involved in cell shape control; contains ankyrin repeats; AKR1 has a paralog, AKR2, that arose from the whole genome duplication (1, 2)
Name Description AnKyrin Repeat-containing protein
Chromosomal Location
ChrIV:998323 to 996029 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All AKR1 GO evidence and references
  View Computational GO annotations for AKR1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 7 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
149 total interaction(s) for 132 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 11
  • Affinity Capture-RNA: 2
  • Biochemical Activity: 6
  • Co-localization: 1
  • Co-purification: 2
  • PCA: 23
  • Two-hybrid: 9

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 73
  • Phenotypic Suppression: 1
  • Positive Genetic: 6
  • Synthetic Growth Defect: 4
  • Synthetic Lethality: 3
  • Synthetic Rescue: 7

Resources
Expression Summary
histogram
Resources
Length (a.a.) 764
Molecular Weight (Da) 85,839
Isoelectric Point (pI) 5.53
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:998323 to 996029 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2295 998323..996029 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002672
References cited on this page View Complete Literature Guide for AKR1
1) Roth AF, et al.  (2002) The yeast DHHC cysteine-rich domain protein Akr1p is a palmitoyl transferase. J Cell Biol 159(1):23-8
2) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61